지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.9
- 수록면
- 231 - 239 (9page)
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초록· 키워드
오류제보하기
Parkinson’s disease (PD), one of common neurodegenerative diseases, is caused by the death of dopaminergic neurons in the substantia nigra pars compacta. The loss of dopaminergic neurons in PD is associated with oxidative stress and mitochondrial dysfunction. Hyperoside (quercetin 3-O-β-D-galactopyranoside) was reported to have protective properties against oxidative stress by reducing intracellular reactive oxygen species (ROS) and increasing antioxidant enzyme activity. In this study, we examined the neuroprotective effect of hyperoside against 1-methyl-4-phenyl pyridinium (MPP<sup>+</sup>)-induced cell model of PD and the underlying molecular mechanisms. Hyperoside significantly decreased MPP<sup>+</sup>-induced cell death, accompanied by a reduction in poly ADP-ribose polymerase (PARP) cleavage. Furthermore, it attenuated MPP<sup>+</sup>-induced intracellular ROS and disruption of mitochondrial membrane potential (MMP), with the reduction of Bax/Bcl-2 ratio. Moreover, hyperoside significantly increased the phosphorylation of Akt, but it has no effects on GSK3β and MAPKs. Pharmacological inhibitor of PI3K/Akt abolished the cytoprotective effects of hyperoside against MPP<sup>+</sup>. Taken together, these results demonstrate that hyperoside significantly attenuates MPP<sup>+</sup>-induced neurotoxicity through PI3K/Akt signaling pathways in SH-SY5Y cells. Our findings suggest that hyperoside might be one of the potential candidates for the treatment of PD.
목차
등록된 정보가 없습니다.
참고문헌 (31)
참고문헌 신청
Fearnley, J. M. / 1991 / Ageing and Parkinson's disease: substantia nigra regional selectivity / Brain 114:2283~2301
Wang, Y. / 2014 / Pinocembrin protects SH-SY5Y cells against MPP+-induced neurotoxicity through the mitochondrial apoptotic pathway / J. Mol Neurosci. 53:537~545
Petit-Paitel, A. / 2009 / Involvment of cytosolic and mitochondrial GSK-$3{\beta}$ in mitochondrial dysfunction and neuronal cell death of MPTP/MPP+-treated neurons / PloS one 4:e5491
Itano, Y. / 1995 / 1-methyl-4-phenyl-pyridinium ion (MPP+) causes DNA fragmentation and increases the Bcl-2 expression in human neuroblastoma, SH-SY5Y cells, through different mechanisms / Brain Res. 704:240~245
Lu, S. / 2011 / Adipose-derived mesenchymal stem cells protect PC12 cells from glutamate excitotoxicity-induced apoptosis by upregulation of XIAP through PI3-K/Akt activation / Toxicology 279:189~195
Wang, Y. / 2014 / Pinocembrin protects SH-SY5Y cells against MPP+-induced neurotoxicity through the mitochondrial apoptotic pathway / J. Mol Neurosci. 53:537~545
Petit-Paitel, A. / 2009 / Involvment of cytosolic and mitochondrial GSK-
Itano, Y. / 1995 / 1-methyl-4-phenyl-pyridinium ion (MPP+) causes DNA fragmentation and increases the Bcl-2 expression in human neuroblastoma, SH-SY5Y cells, through different mechanisms / Brain Res. 704:240~245
Lu, S. / 2011 / Adipose-derived mesenchymal stem cells protect PC12 cells from glutamate excitotoxicity-induced apoptosis by upregulation of XIAP through PI3-K/Akt activation / Toxicology 279:189~195
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