지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.9
- 수록면
- 119 - 124 (6page)
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Vaginal microbiome deeply influences vaginal health via production of messenger molecules. The healthy vaginal pH ranges between 3.5 and 4.5. However, dysbiosis of vaginal microbiome increases the pH level, leading to the incidence of vaginitis. The commensal vaginal bacterium Dermabacter vaginalis―which was isolated from the vaginal fluid of a Korean female―was incubated in acidic and neutral pH to simulate healthy and vaginitis conditions, respectively. The chemical profiles of the two different cultures were compared using HPLC. The compound showing distinctive difference between the two sets of data was presumed to be a chemical messenger, which was identified as cyclo(L-pro-L-met) by analysis of NMR, MS, and specific rotation data. Synthesis was achieved in three steps (overall yield 15%), enabling structure confirmation and antimicrobial evaluation against vaginal pathogens. Cyclo(L-pro-L-met) showed antifungal activity against Candida albicans, a major cause of vulvovaginal candidiasis.
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Abstract
재료 및 방법
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참고문헌 (15)
참고문헌 신청
Blum, H. E. (2017) The human microbiome. Adv. Med. Sci. 62: 414-420.
Smits, W. K., Lyras, D., Lacy, D. B., Wilcox, M. H. and Kuijper, E. J. (2016) Clostridium difficile infection. Nat. Rev. Dis. Primers 2: 16020.
Gilbert, J. A., Blaser, M. J., Caporaso, J. G., Jansson, J. K., Lynch, S. V. and Knight, R. (2018) Current understanding of the human microbiome. Nat. Med. 24: 392-400.
Proctor, L., LoTempio, J., Marquitz, A., Daschner, P., Xi, D., Flores, R., Brown, L., Ranallo, R., Maruvada, P., Regan, K., Lunsford, R.D., Reddy, M. and Caler, L. (2019) A review of 10 years of human microbiome research activities at the US National Institutes of Health, Fiscal Years 2007-2016. Microbiome 7: 31.
Saraf, V. S., Sheikh, S. A., Ahmad, A., Gillevet, P. M., Bokhari, H. and Javed, S. (2021) Vaginal microbiome: normalcy vs dysbiosis. Arch. Microbiol. 203: 3793-3802.
Smits, W. K., Lyras, D., Lacy, D. B., Wilcox, M. H. and Kuijper, E. J. (2016) Clostridium difficile infection. Nat. Rev. Dis. Primers 2: 16020.
Gilbert, J. A., Blaser, M. J., Caporaso, J. G., Jansson, J. K., Lynch, S. V. and Knight, R. (2018) Current understanding of the human microbiome. Nat. Med. 24: 392-400.
Proctor, L., LoTempio, J., Marquitz, A., Daschner, P., Xi, D., Flores, R., Brown, L., Ranallo, R., Maruvada, P., Regan, K., Lunsford, R.D., Reddy, M. and Caler, L. (2019) A review of 10 years of human microbiome research activities at the US National Institutes of Health, Fiscal Years 2007-2016. Microbiome 7: 31.
Saraf, V. S., Sheikh, S. A., Ahmad, A., Gillevet, P. M., Bokhari, H. and Javed, S. (2021) Vaginal microbiome: normalcy vs dysbiosis. Arch. Microbiol. 203: 3793-3802.
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