지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.9
- 수록면
- 145 - 152 (8page)
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초록· 키워드
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Type II diabetes mellitus (T2DM) is a chronic metabolic disease caused by insulin resistance, and abnormally elevated hepatic gluconeogenesis is characterized. Phillyrin, one of the major active constituents of Forsythia suspense, is known to possess the anti-inflammatory and anti-oxidant effects. However, the anti-diabetes mellitus effect of phillyrin and its molecular mechanisms are unclear. The aim of the current study was to investigate the role of phillyrin on gluconeogenesis in insulin resistant HepG2 cells. Phillyrin suppressed high glucose (HG)-induced glucose production. In addition, phillyrin reduced HGinduced the expression of phosphoenolpyruvate carboxykinase (PEPCK) and glucose 6-phosphatase (G6Pase), major genes in hepatic gluconeogenesis. Phillyrin treatment attenuated HG-induced nucleus protein levels of FOXO1 and HDAC5 and increased the phosphorylation of Akt, AMPK, HDAC5, and FOXO1. The block of AMPK and Akt activity did not exert the inhibitory effect of phillyrin on gluconeogenesis in insulin resistant HepG2. Taken together, these results suggest that phillyrin inhibits gluconeogenesis of hepatocytes to improve glucose metabolism, through the regulation of LKB1/AMPK/HDAC5 and PI3K/AKT/FOXO1 pathway. These results indicate that phillyrin may be useful in improving hepatic gluconeogenesis associated with insulin resistant and T2DM.
목차
Abstract
재료 및 방법
결과 및 고찰
결론
인용문헌
참고문헌 (34)
참고문헌 신청
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Aji, G., Huang, Y., Ng, M. L., Wang, W., Lan, T., Li, M., Li, Y., Chen, Q., Li, R., Yan, S., Tran, C., Burchfield, J. G., Couttas, T. A., Chen, J., Chung, L. H., Liu, D., Wadham, C., Hogg, P. J., Gao, X., Vadas, M. A., Gamble, J. R., Don, A. S., Xia, P. and Qi, Y. (2020) Regulation of hepatic insulin signaling and glucose homeostasis by sphingosine kinase 2. Proc. Natl. Acad. Sci. USA 117: 24434-24442.
Tomita, T. (2016) Apoptosis in pancreatic beta-islet cells in type 2 diabetes. Bosn. J. Basic Med. Sci. 16: 162-179.
Gu, L., Ding, X., Wang, Y., Gu, M., Zhang, J., Yan, S., Li, N., Song, Z., Yin, J., Lu, L. and Peng, Y. (2019) Spexin alleviates insulin resistance and inhibits hepatic gluconeogenesis via the FoxO1/PGC-1alpha pathway in high-fat-diet-induced rats and insulin resistant cells. Int. J. Biol. Sci. 15: 2815-2829.
Sharma, M. D., Garber, A. J. and Farmer, J. A. (2008) Role of insulin signaling in maintaining energy homeostasis. Endocr. Pract. 14: 373-380.
Aji, G., Huang, Y., Ng, M. L., Wang, W., Lan, T., Li, M., Li, Y., Chen, Q., Li, R., Yan, S., Tran, C., Burchfield, J. G., Couttas, T. A., Chen, J., Chung, L. H., Liu, D., Wadham, C., Hogg, P. J., Gao, X., Vadas, M. A., Gamble, J. R., Don, A. S., Xia, P. and Qi, Y. (2020) Regulation of hepatic insulin signaling and glucose homeostasis by sphingosine kinase 2. Proc. Natl. Acad. Sci. USA 117: 24434-24442.
Tomita, T. (2016) Apoptosis in pancreatic beta-islet cells in type 2 diabetes. Bosn. J. Basic Med. Sci. 16: 162-179.
Gu, L., Ding, X., Wang, Y., Gu, M., Zhang, J., Yan, S., Li, N., Song, Z., Yin, J., Lu, L. and Peng, Y. (2019) Spexin alleviates insulin resistance and inhibits hepatic gluconeogenesis via the FoxO1/PGC-1alpha pathway in high-fat-diet-induced rats and insulin resistant cells. Int. J. Biol. Sci. 15: 2815-2829.
Sharma, M. D., Garber, A. J. and Farmer, J. A. (2008) Role of insulin signaling in maintaining energy homeostasis. Endocr. Pract. 14: 373-380.
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