Clinical Characteristics and Pregnancy-Related Outcomes of Pregnant Women Hospitalized with COVID-19 During the Delta Wave: A Single-Center Observational Study

Hong Shin Hee; Shi Hye Jin; Kim Suk Young; Park Yoonseon; Eom Joong Sik

doi:10.3947/ic.2022.0072

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저자정보: Hong Shin Hee (Division of Infectious Diseases Department of Internal Medicine Gil Medical Center Gachon Universit) Shi Hye Jin (Division of Infectious Diseases Department of Internal Medicine Gil Medical Center Gachon Universit) Kim Suk Young (Department of Obstetrics and Gynecology Gil Medical Center Gachon University College of Medicine In) Park Yoonseon (Division of Infectious Diseases Department of Internal Medicine Gil Medical Center Gachon Universit) Eom Joong Sik (Division of Infectious Diseases Department of Internal Medicine Gil Medical Center Gachon Universit)

저널정보: 대한감염학회 Infection and Chemotherapy Infection and Chemotherapy 제54권 제3호

발행연도: 2022.9

수록면: 433 - 445 (13page)

DOI: 10.3947/ic.2022.0072

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Background Coronavirus disease 2019 (COVID-19) during pregnancy is associated with increased disease severity and an increased risk of perinatal complications. However, few studies of pregnant women with COVID-19 have been conducted in Korea. The purpose of this study was to describe the clinical course and pregnancy outcomes of pregnant women admitted to our hospital with COVID-19 according to the severity. Materials and Methods This retrospective cohort study included women aged 18 years of age or older who were hospitalized in the Gachon University Gil Medical Center with COVID-19 during pregnancy between July 1, 2021 and January 31, 2022. COVID-19 severity was classified according to the “Criteria for severity classification by symptoms of COVID-19” presented by the Korea Disease Control and Prevention Agency. Severe cases were defined as those who required oxygen treatment administered via a high-flow nasal cannula or invasive mechanical ventilation or should be applied extracorporeal membrane oxygenation (ECMO) or continuous renal replacement therapy. Results A total of 103 pregnant women were hospitalized with COVID-19 during the study period. Their mean age was 33 (± 4.14) years, and 4 (3.9%) had been vaccinated against COVID-19. At the time of diagnosis of COVID-19, 3 (2.9%), 33 (32.0%), and 67 (65.1%) patients were in the first, second, and third trimester, respectively. The most common symptoms were cough (99 patients, 96.1%) and fever (85 patients, 82.5%). There was 1 (1.0%) asymptomatic patient. Forty patients (38.8%) required supplemental oxygen and 19 patients (18.4%) had severe disease. Of the 19 severe cases, 7 were in the 2nd trimester and 12 were in the 3rd trimester. Forty-one (39.8%) patients delivered, including two twin deliveries. Of the 41 cases of delivery, 14 were premature, 4 out of 21 (19.0%) in mild, 4 out of 12 (25.0%) in moderate, and 6 out of 8 (75.0%) in severe. Severe disease was associated with an increased rate of preterm birth (P = 0.012). Four of the 43 neonates (9.1%) received oxygen treatment. Conclusion Pregnant women with COVID-19 had a high rate of severe disease and a high preterm delivery rate, especially among those with severe disease.

Background Coronavirus disease 2019 (COVID-19) during pregnancy is associated with increased disease severity and an increased risk of perinatal complications. However, few studies of pregnant women with COVID-19 have been conducted in Korea. The purpose of this study was to describe the clinical course and pregnancy outcomes of pregnant women admitted to our hospital with COVID-19 according to the severity. Materials and Methods This retrospective cohort study included women aged 18 years of age or older who were hospitalized in the Gachon University Gil Medical Center with COVID-19 during pregnancy between July 1, 2021 and January 31, 2022. COVID-19 severity was classified according to the “Criteria for severity classification by symptoms of COVID-19” presented by the Korea Disease Control and Prevention Agency. Severe cases were defined as those who required oxygen treatment administered via a high-flow nasal cannula or invasive mechanical ventilation or should be applied extracorporeal membrane oxygenation (ECMO) or continuous renal replacement therapy. Results A total of 103 pregnant women were hospitalized with COVID-19 during the study period. Their mean age was 33 (± 4.14) years, and 4 (3.9%) had been vaccinated against COVID-19. At the time of diagnosis of COVID-19, 3 (2.9%), 33 (32.0%), and 67 (65.1%) patients were in the first, second, and third trimester, respectively. The most common symptoms were cough (99 patients, 96.1%) and fever (85 patients, 82.5%). There was 1 (1.0%) asymptomatic patient. Forty patients (38.8%) required supplemental oxygen and 19 patients (18.4%) had severe disease. Of the 19 severe cases, 7 were in the 2nd trimester and 12 were in the 3rd trimester. Forty-one (39.8%) patients delivered, including two twin deliveries. Of the 41 cases of delivery, 14 were premature, 4 out of 21 (19.0%) in mild, 4 out of 12 (25.0%) in moderate, and 6 out of 8 (75.0%) in severe. Severe disease was associated with an increased rate of preterm birth (P = 0.012). Four of the 43 neonates (9.1%) received oxygen treatment. Conclusion Pregnant women with COVID-19 had a high rate of severe disease and a high preterm delivery rate, especially among those with severe disease.

#COVID-19 #SARS-CoV-2 #Disease severity #Pregnancy #Premature birth

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Hong Shin Hee

소속기관 Division of Infectious Diseases Department of Internal Medicine Gil Medical Center Gachon Universit

주요연구분야 의약학 > 의학 일반 의약학 > 임상의학 > 내과학

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Shi Hye Jin

소속기관 Division of Infectious Diseases, Department of Internal Medicine, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea.

주요연구분야 의약학 > 의학 일반 의약학 > 임상의학 > 내과학

논문수 8 이용수 8

Kim Suk Young

소속기관 Department of Obstetrics and Gynecology Gil Medical Center Gachon University College of Medicine In

주요연구분야 의약학 > 임상의학 > 내과학

논문수 1 이용수 1

Park Yoonseon

소속기관 Division of Infectious Diseases Department of Internal Medicine Gil Medical Center Gachon University College of Medicine Incheon Korea.

주요연구분야 의약학 > 임상의학 > 내과학

논문수 2 이용수 2

Eom Joong Sik

소속기관 Division of Infectious Diseases Department of Internal Medicine Gil Medical Center Gachon University College of Medicine Incheon Korea.

주요연구분야 의약학 > 임상의학 > 내과학

논문수 3 이용수 2

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