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논문 기본 정보

자료유형
학술저널
저자정보
Shin Jaeseung (Department of Radiology and Research Institute of Radiological Science Severance Hospital Yonsei Un) Lee Sunyoung (Department of Radiology and Research Institute of Radiological Science Severance Hospital Yonsei Un) Kim Yeun-Yoon (Department of Radiology and Research Institute of Radiological Science Severance Hospital) Chung Yong Eun (Department of Radiology Severance Hospital Yonsei University College of Medicine Seoul Korea.) Choi Jin-Young (Department of Radiology and Research Institute of Radiological Science Severance Hospital Yonsei Un) Park Mi-Suk (Department of Radiology Severance Hospital Yonsei University College of Medicine Seoul Korea.)
저널정보
대한초음파의학회 ULTRASONOGRAPHY ULTRASONOGRAPHY Vol.41 No.1
발행연도
2022.1
수록면
74 - 82 (9page)
DOI
10.14366/usg.21011

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Purpose: A meta-analysis was conducted to determine the proportion of contrast-enhanced ultrasound (CEUS) Liver Imaging Reporting and Data System category M (LR-M) in hepatocellular carcinomas (HCCs) and non-HCC malignancies and to investigate the frequency of individual CEUS LR-M imaging features.Methods: The MEDLINE and Embase databases were searched from January 1, 2016 to July 23, 2020 for studies reporting the proportion of CEUS LR-M in HCC and non-HCC malignancies. The meta-analytic pooled proportions of HCC and non-HCC malignancies in the CEUS LR-M category were calculated. The meta-analytic frequencies of CEUS LR-M imaging features in nonHCC malignancies were also determined. Risk of bias and applicability were evaluated using the Quality Assessment of Diagnostic Accuracy Studies-2 tool.Results: Twelve studies reporting the diagnostic performance of the CEUS LR-M category were identified, as well as seven studies reporting the frequencies of individual CEUS LR-M imaging features. The pooled proportions of HCC and non-HCC malignancies in the CEUS LR-M category were 54% (95% confidence interval [CI], 44% to 65%) and 40% (95% CI, 28% to 53%), respectively. The pooled frequencies of individual CEUS LR-M imaging features in non-HCC malignancies were 30% (95% CI, 17% to 45%) for rim arterial phase hyperenhancement, 79% (95% CI, 66% to 90%) for early (<60 s) washout, and 42% (95% CI, 21% to 64%) for marked washout.Conclusion: In total, 94% of CEUS LR-M lesions were malignancies, with HCCs representing 54% and non-HCC malignancies representing 40%. The frequencies of individual CEUS LR-M imaging features varied; early washout showed the highest frequency for non-HCC malignancies.

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