지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.10
- 수록면
- 800 - 809 (10page)
- DOI
- https://doi.org/10.3803/EnM.2022.1462
이용수
초록· 키워드
오류제보하기
Background: Excessive proliferation and migration of vascular smooth muscle cells (VSMCs), which contributes to the development of occlusive vascular diseases, requires elevated mitochondrial oxidative phosphorylation to meet the increased requirements for energy and anabolic precursors. Therefore, therapeutic strategies based on blockade of mitochondrial oxidative phosphorylation are considered promising for treatment of occlusive vascular diseases. Here, we investigated whether DN200434, an orally available estrogen receptor-related gamma inverse agonist, inhibits proliferation and migration of VSMCs and neointima formation by suppressing mitochondrial oxidative phosphorylation. Methods: VSMCs were isolated from the thoracic aortas of 4-week-old Sprague-Dawley rats. Oxidative phosphorylation and the cell cycle were analyzed in fetal bovine serum (FBS)- or platelet-derived growth factor (PDGF)-stimulated VSMCs using a Seahorse XF-24 analyzer and flow cytometry, respectively. A model of neointimal hyperplasia was generated by ligating the left common carotid artery in male C57BL/6J mice. Results: DN200434 inhibited mitochondrial respiration and mammalian target of rapamycin complex 1 activity and consequently suppressed FBS- or PDGF-stimulated proliferation and migration of VSMCs and cell cycle progression. Furthermore, DN200434 reduced carotid artery ligation-induced neointima formation in mice. Conclusion: Our data suggest that DN200434 is a therapeutic option to prevent the progression of atherosclerosis.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Therapeutic targets and drugs for hyper-proliferation of vascular smooth muscle cells
Journal of Pharmaceutical Investigation
2020 .01
-
Glucagon-Like Peptide Receptor Agonist Inhibits Angiotensin II-Induced Proliferation and Migration in Vascular Smooth Muscle Cells and Ameliorates Phosphate-Induced Vascular Smooth Muscle Cells Calcification
Diabetes and Metabolism Journal
2024 .01
-
Anti-malarial Drugs Reduce Vascular Smooth Muscle Cell Proliferation via Activation of AMPK and Inhibition of Smad3 Signaling
지질·동맥경화학회지
2019 .01
-
Lactate promotes vascular smooth muscle cell switch to a synthetic phenotype by inhibiting miR-23b expression
The Korean Journal of Physiology & Pharmacology
2022 .11
-
Murrayafoline A Induces a G0/G1-Phase Arrest in Platelet-Derived Growth Factor-Stimulated Vascular Smooth Muscle Cells
The Korean Journal of Physiology & Pharmacology
2015 .09
-
Gallic Acid Inhibits Proliferation and Migration of Smooth Muscle Cells in a Pig In-Stent Restenosis Model
전남의대학술지
2024 .01
-
DE21 inhibits PDGF-induced proliferation of rat aortic vascular smooth muscle cell by up-regulation of p53 leading to G1/S cell cycle arrest
한국실험동물학회 학술발표대회 논문집
2015 .02
-
Anti-apoptotic effects of autophagy via ROS regulation in microtubule-targeted and PDGF-stimulated vascular smooth muscle cells
The Korean Journal of Physiology & Pharmacology
2018 .05
-
Effect of imatinib mesylate and rapamycin on the preformed intimal hyperplasia in rat carotid injury model
Annals of Surgical Treatment and Research
2015 .02
-
Modulation of Vascular Smooth Muscle Cell Phenotype by High Mobility Group AT-Hook 1
지질·동맥경화학회지
2021 .01
-
Protective effect and mechanism of ginsenoside Rg2 on atherosclerosis
Journal of Ginseng Research
2023 .03
-
Wogonin attenuates vascular remodeling by inhibiting smooth muscle cell proliferation and migration in hypertensive rat
The Korean Journal of Physiology & Pharmacology
2024 .01
-
The New Weapon to Inhibit Proliferation and Migration of Smooth Muscle Cell in Neointimal Formation
Korean Circulation Journal
2020 .01
-
α-Isocubebene modulates vascular tone by inhibiting myosin light chain phosphorylation in murine thoracic aorta
The Korean Journal of Physiology & Pharmacology
2018 .07
-
Dendropanax morbifera Extract Inhibits Intimal Hyperplasia in Balloon-Injured Rat Carotid Arteries by Modulating Phenotypic Changes in Vascular Smooth Muscle Cells
Natural Product Sciences
2020 .03
-
Arginase Inhibition Suppresses Native Low-Density Lipoprotein-Stimulated Vascular Smooth Muscle Cell Proliferation by NADPH Oxidase Inactivation
Yonsei Medical Journal
2018 .01
-
Anti-Proliferative Effects of Rutin on OLETF Rat Vascular Smooth Muscle Cells Stimulated by Glucose Variability
Yonsei Medical Journal
2016 .01
-
Effects of Homocysteine and Hyperglycemia on the Proliferation of Aortic Vascular Smooth Muscle Cells of Obese Type 2 Diabetes Rat
Annals of geriatric medicine and research
2017 .01
-
Heat shock protein 90 inhibitor AUY922 attenuates platelet-derived growth factor-BB-induced migration and proliferation of vascular smooth muscle cells
The Korean Journal of Physiology & Pharmacology
2020 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0