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논문 기본 정보

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학술저널
저자정보
Darren Jun Hao Tan (Yong Loo Lin School of Medicine National University of Singapore) Sabrina Xin Zi Quek (Yong Loo Lin School of Medicine National University of Singapore) Jie Ning Yong (Yong Loo Lin School of Medicine National University of Singapore) Adithya Suresh (Yong Loo Lin School of Medicine National University of Singapore) Kaiser Xuan Ming Koh (Yong Loo Lin School of Medicine National University of Singapore) Wen Hui Lim (Yong Loo Lin School of Medicine National University of Singapore) Jingxuan Quek (Yong Loo Lin School of Medicine National University of Singapore) Ansel Tang (Yong Loo Lin School of Medicine National University of Singapore) Caitlyn Tan (Yong Loo Lin School of Medicine National University of Singapore) Benjamin Nah (Division of Gastroenterology and Hepatology Department of Medicine National University Hospital) Eunice Tan (Yong Loo Lin School of Medicine National University of Singapore) Taisei Keitoku (Department of Gastroenterology and Hepatology Musashino Red Cross Hospital) Mark D. Muthiah (Yong Loo Lin School of Medicine National University of Singapore) Nicholas Syn (Yong Loo Lin School of Medicine National University of Singapore) Cheng Han Ng (Yong Loo Lin School of Medicine National University of Singapore) Beom Kyung Kim (Department of Internal Medicine Yonsei University College of Medicine) Nobuharu Tamaki (Department of Gastroenterology and Hepatology Musashino Red Cross Hospital) Cyrus Su Hui Ho (Yong Loo Lin School of Medicine National University of Singapore) Rohit Loomba (NAFLD Research Center Division of Medicine University of California San Diego) Daniel Q Huang (Yong Loo Lin School of Medicine National University of Singapore)
저널정보
대한간학회 Clinical and Molecular Hepatology Clinical and Molecular Hepatology 제28권 제4호
발행연도
2022.10
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864 - 875 (12page)

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Background/Aims: Depression and anxiety are associated with poorer outcomes in patients with hepatocellular carcinoma (HCC). However, the prevalence of depression and anxiety in HCC are unclear. We aimed to establish the prevalence of depression and anxiety in patients with HCC. Methods: MEDLINE and Embase were searched and original articles reporting prevalence of anxiety or depression in patients with HCC were included. A generalized linear mixed model with Clopper-Pearson intervals was used to obtain the pooled prevalence of depression and anxiety in patients with HCC. Risk factors were analyzed via a fractional-logistic regression model. Results: Seventeen articles involving 64,247 patients with HCC were included. The pooled prevalence of depression and anxiety in patients with HCC was 24.04% (95% confidence interval [CI], 13.99–38.11%) and 22.20% (95% CI, 10.07–42.09%) respectively. Subgroup analysis determined that the prevalence of depression was lowest in studies where depression was diagnosed via clinician-administered scales (16.07%;95% CI, 4.42–44.20%) and highest in self-reported scales (30.03%; 95% CI, 17.19–47.01%). Depression in patients with HCC was lowest in the Americas (16.44%; 95% CI, 6.37–36.27%) and highest in South-East Asia (66.67%; 95% CI, 56.68–75.35%). Alcohol consumption, cirrhosis, and college education significantly increased risk of depression in patients with HCC. Conclusions: One in four patients with HCC have depression, while one in five have anxiety. Further studies are required to validate these findings, as seen from the wide CIs in certain subgroup analyses. Screening strategies for depression and anxiety should also be developed for patients with HCC.
#Depression #Anxiety #Hepatocellular carcinoma #Meta-analysis #Systematic review

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