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논문 기본 정보

자료유형
학술저널
저자정보
Johannes Kersten (Internal Medicine II) Carsten Hackenbroch (Armed Forces Military Hospital Ulm) Muriel Bouly (Institut de Recherches Internationales Servier) Benoit Tyl (Institut de Recherches Internationales Servier) Peter Bernhardt (Heart Clinic Ulm)
저널정보
한국심초음파학회 Journal of Cardiovascular Imaging Journal of Cardiovascular Imaging 제30권 제3호
발행연도
2022.7
수록면
202 - 211 (10page)

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BACKGROUND: This study aims to investigate normal changes throughout aging of the heart in cardiac magnetic resonance (CMR) imaging in healthy volunteers. While type 2 diabetes mellitus is a frequent finding in the elderly population, also the influence of this circumstance in otherwise healthy persons is part of our study. METHODS: In this prospective single-center trial, 75 healthy subjects in distinct age groups and 10 otherwise healthy diabetics were enrolled. All subjects underwent functional, flow sensitive, native T2- and T1-mapping in a 1.5T CMR scanner. RESULTS: No differences in right and left ventricular ejection fractions were observed between aging healthy groups. Bi-ventricular volumes lowered significantly (p<0.001) between the age groups. There was also a significant decrease in myocardial T1 values, aortic distensibility, and left ventricular peak diastolic strain rates. There were no differences in T2 mapping and the other deformation parameters. Patients with type 2 diabetes mellitus had lower end-diastolic volume indexes; all the other measurements were comparable. CONCLUSIONS: Aging processes in the healthy heart involve a decrease in ventricular volumes, with ejection fractions remaining normal. Stiffening of the myocardium and aorta and a decrease in T1 values are potential indications of age-related remodeling. Type 2 diabetes mellitus seems to have no major influence on aging processes of the heart.

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