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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 11 - 17 (7page)
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Autophagy is critical for the maintenance of organelle function and intracellular nutrient environment. Autophagy is also involved in systemic metabolic homeostasis, and its dysregulation can lead to or accelerate the development of metabolic disorders. While the role of autophagy in the global metabolism of model organisms has been investigated mostly using site-specific genetic knockout technology, the impact of dysregulated autophagy on systemic metabolism has been unclear. Here, we review recent papers showing the role of autophagy in systemic metabolism and in the development of metabolic disorders. Also included are data suggesting the role of autophagy in human-type diabetes, which are different in several key aspects from murine models of diabetes. The results shown here support the view that autophagy modulation could be a new modality for the treatment of metabolic syndrome associated with lipid overload and human-type diabetes.
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참고문헌 (54)
참고문헌 신청
Castillo, K. / 2013 / Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons / Autophagy 9:1308~1320
Coupe, B. / 2012 / Loss of autophagy in pro-opiomelanocortin neurons perturbs axon growth and causes metabolic dysregulation / Cell Metab 15:1~9
Dehay, B. / 2010 / Pathogenic lysosomal depletion in Parkin's disease / Neurobiol. Dis. 30:12534~12544
Ebato, C. / 2008 / Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet / Cell Metab 8:325~332
Eisenberg, T. / 2009 / Induction of autophagy by spermidine promotes longevity / Nature Cell Biol 11:1305~1314
Coupe, B. / 2012 / Loss of autophagy in pro-opiomelanocortin neurons perturbs axon growth and causes metabolic dysregulation / Cell Metab 15:1~9
Dehay, B. / 2010 / Pathogenic lysosomal depletion in Parkin's disease / Neurobiol. Dis. 30:12534~12544
Ebato, C. / 2008 / Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet / Cell Metab 8:325~332
Eisenberg, T. / 2009 / Induction of autophagy by spermidine promotes longevity / Nature Cell Biol 11:1305~1314
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