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Jun Ho Yi (Chung-Ang University Hospital) 이경원 (경상국립대학교) 이지현 (동아대학교) Kwai Han Yoo (Division of Hematology-Oncology, Gachon University College of Medicine) Chul Won Jung (Sungkyunkwan University School of Medicine) Dae Sik Kim (Korea University Guro Hospital) Jeong-Ok Lee (Department of Internal Medicine Seoul National University Bundang Hospital) Hyeon Seok Eom (National Cancer Center) Ja Min Byun (Division of Hematology and Medical Oncology, Department of Internal Medicine, Seoul National Univer) Youngil Koh (Department of Hematology/Oncology Seoul National University Hospital) Sung Soo Yoon (Seoul National University Hospital) Jin Seok Kim (Division of Hematology, Department of Internal Medicine, Severance Hospital, Yonsei University Coll) Jee Hyun Kong (Yonsei University Wonju College of Medicine) Ho-Young Yhim (Department of Hematology/Oncology Jeonbuk National University Hospital) Deok Hwan Yang (Chonnam National University Hwasun Hospital) Dok Hyun Yoon (Asan Medical Center) Do Hyoung Lim (Division of Hematology-Oncology, Department of Medicine, Dankook University College of Medicine) Won Sik Lee (Inje University Busan Baik Hospital) Ho Jin Shin (Department of Hematology/Oncology Pusan National University Hospital)
저널정보
대한혈액학회 Blood Research Blood Research Vol.56 No.4
발행연도
2021.12
수록면
243 - 251 (9page)
DOI
10.5045/br.2021.2021102

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Background Chronic lymphocytic leukemia (CLL) is the most common type of adult leukemia in Western countries but is rare in the East Asian countries. Due to its rarity and the lack of feasible novel agents and laboratory prognostic tools, there are limited data on the clinical outcomes of this disease in Asia. To clarify the current treatment status, we performed a multicenter retrospective analysis of patients with CLL in Korea. Methods The medical records of 192 eligible patients between 2008 and 2019 were reviewed for clinical characteristics, treatment courses, and outcomes. The first-line treatment regimens of the patients included in this analysis were as follows: fludarabine/cyclophosphamide/ rituximab (FCR) (N=117, 52.7%), obinutuzumab plus chlorambucil (GC) (N=30, 13.5%), and chlorambucil monotherapy (N=24, 10.8%). Results The median progression-free survival (PFS) was 55.6 months, and the average 2-year PFS rate was 80.3%. PFS was not significantly different between the patients receiving FCR and those receiving GC; however, chlorambucil treatment was associated with significantly inferior PFS (P ＜0.001). The median overall survival was 136.3 months, and the average 5- and 10-year OS rates were 82.0% and 57.4%, respectively. Conclusion This is one of the largest studies involving Korean patients with CLL. Although the patients had been treated with less favored treatment regimens, the outcomes were not different from those reported in Western studies.
#Chronic lymphocytic leukemia #Outcomes #Asia

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참고문헌 신청
Teras LR / 2016 / 2016 US lymphoid malignancy statistics by World Health Organization subtypes / CA Cancer J Clin 66:443~459 google schola Siegel RL / 2019 / Cancer statistics, 2019 / CA Cancer J Clin 69:7~34 google schola Döhner H / 2000 / Genomic aberrations and survival in chronic lymphocytic leukemia / N Engl J Med 343:1910~1916 google schola International CLL-IPI working group / 2016 / An international prognostic index for patients with chronic lymphocytic leukaemia(CLL-IPI) : a meta-analysis of individual patient data / Lancet Oncol 17:779~790 google schola Abrisqueta P / 2009 / Improving survival in patients with chronic lymphocytic leukemia(1980-2008) : the Hospital Clinic of Barcelona experience / Blood 114:2044~2050 google schola

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