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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제21권 제6호
- 발행연도
- 2017.11
- 수록면
- 695 - 702 (8page)
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초록· 키워드
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The sustained tonic currents (Itonic) generated by γ-aminobutyric acid A receptors (GABAARs) are implicated in diverse age-dependent brain functions. While various mechanisms regulating Itonic in the hippocampus are known, their combined role in Itonic regulation is not well understood in different age groups. In this study, we demonstrated that a developmental increase in GABA transporter (GAT) expression, combined with gradual decrease in GABAAR a5 subunit, resulted in various Itonic in the dentate gyrus granule cells (DGGCs) of preadolescent rats. Both GAT-1 and GAT- 3 expression gradually increased at infantile (P6-8 and P13-15) and juvenile (P20-22 and P27-29) stages, with stabilization observed thereafter in adolescents (P34-36) and young adults (P41-43). Itonic facilitation of a selective GAT-1 blocker (NO-711) was significantly less at P6-8 than after P13-15. The facilitation of Itonic by SNAP-5114, a GAT-3 inhibitor, was negligible in the absence of exogenous GABA at all tested ages. In contrast, Itonic in the presence of a nonselective GAT blocker (nipecotic acid, NPA) gradually decreased with age during the preadolescent period, which was mimicked by Itonic changes in the presence of exogenous GABA. Itonic sensitivity to L-655,708, a GABAAR a5 subunit inverse agonist, gradually decreased during the preadolescent period in the presence of NPA or exogenous GABA. Finally, Western blot analysis showed that the expression of the GABAAR a5 subunit in the dentate gyrus gradually decreased with age. Collectively, our results suggested that the Itonic regulation of altered GATs is under the final tune of GABAAR a5 subunit activation in DGGCs at different ages.
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등록된 정보가 없습니다.
참고문헌 (32)
참고문헌 신청
Farrant M / 2005 / Variations on an inhibitory theme : phasic and tonic activation of GABA(A)receptors / Nat Rev Neurosci 6:215~229
Semyanov A / 2004 / Tonically active GABA A receptors : modulating gain and maintaining the tone / Trends Neurosci 27:262~269
Brickley SG / 2012 / Extrasynaptic GABA(A)receptors : their function in the CNS and implications for disease / Neuron 73:23~34
Hines RM / 2012 / Functional regulation of GABAA receptors in nervous system pathologies / Curr Opin Neurobiol 22:552~558
장현종 / 2010 / The Development of Phasic and Tonic Inhibition in the Rat Visual Cortex / The Korean Journal of Physiology & Pharmacology 14(6):399~405
Semyanov A / 2004 / Tonically active GABA A receptors : modulating gain and maintaining the tone / Trends Neurosci 27:262~269
Brickley SG / 2012 / Extrasynaptic GABA(A)receptors : their function in the CNS and implications for disease / Neuron 73:23~34
Hines RM / 2012 / Functional regulation of GABAA receptors in nervous system pathologies / Curr Opin Neurobiol 22:552~558
장현종 / 2010 / The Development of Phasic and Tonic Inhibition in the Rat Visual Cortex / The Korean Journal of Physiology & Pharmacology 14(6):399~405
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