지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 1,223 - 1,236 (14page)
- DOI
- https://doi.org/10.22246/jikm.2021.42.6.1223
이용수
초록· 키워드
오류제보하기
Objectives: The aim of the current study was to investigate the effect of Sosiho-tang on thioacetamide (TAA)-induced liver fibrosis in mice and to elucidate its underlying mechanisms.
Methods: The mice were divided into 4 groups: Normal mice (Normal), TAA-induced control mice (Control), TAA-induced and silymarin-treated (50 mg/kg) mice (Silymarin), and TAA-induced and Sosiho-tang treated (200 mg/kg) mice (SSHT). Liver fibrosis was induced via intraperitoneal injection of TAA three times a week for 8 weeks. Silymarin and Sosiho-tang were concomitantly administered for 8 weeks. Serum and liver tissues were then collected and the anti-oxidant and inflammatory protein levels in the liver tissues were evaluated using western blotting.
Results: SSHT administration significantly reduced the levels of AST, ALT, ammonia, and MPO in the serum. SSHT also significantly down-regulated liver NADPH oxidase and regulated the Nrf2/Keap1 signaling pathway. SSHT treatment downregulated the liver NF-κB levels and suppressed inflammatory cytokines. SSHT treatment also decreased bile acid-related factors, such as CYP7A1 and NTCP, and fibrosis-related factors, such as α-SMA and Collagen Ⅰ.
Conclusions: Taken together, these data suggest that SSHT administration suppressed the progression of liver fibrosis by activating the Nrf2/Keap1 pathway and inhibiting NF-κB.
목차
등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
Feng J / 2018 / Salidroside ameliorates autophagy and activation of hepatic stellate cells in mice via NF-kappaB and TGF-beta1/Smad3 pathways / Drug Des Devel Ther 12:1837~1853
Tu T / 2015 / Hepatocytes in liver injury:Victim, bystander, or accomplice in progressive fibrosis? / J Gastroenterol Hepatol 30(12):1696~1704
Nieto N / 2002 / Stimulation and proliferation of primary rat hepatic stellate cells by cytochrome P4502E1-derived reactive oxygen species / Hepatology 35(1):62~73
Sánchez-Valle V / 2012 / Role of oxidative stress and molecular changes in liver fibrosis: a review / Curr Med Chem 19(28):4850~4860
大韓藥師會 / 1995 / 韓藥調劑指針解說 / 여강출판사
Tu T / 2015 / Hepatocytes in liver injury:Victim, bystander, or accomplice in progressive fibrosis? / J Gastroenterol Hepatol 30(12):1696~1704
Nieto N / 2002 / Stimulation and proliferation of primary rat hepatic stellate cells by cytochrome P4502E1-derived reactive oxygen species / Hepatology 35(1):62~73
Sánchez-Valle V / 2012 / Role of oxidative stress and molecular changes in liver fibrosis: a review / Curr Med Chem 19(28):4850~4860
大韓藥師會 / 1995 / 韓藥調劑指針解說 / 여강출판사
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