지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 183 - 191 (9page)
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초록· 키워드
오류제보하기
Behcet’s disease (BD) is a multisystem disease in which environmental factors provoke an adverse immune response in patients with genetic susceptibility towards BD, subsequently leading to a cascade of dysregulated inflammation throughout the body. It is particularly prevalent in regions spanning the ancient Silk Road, including Korea, where the first known case of BD was reported in 1961. We summarize the history, epidemiology, and clinical presentation of BD in Korea, highlighting the clinical tendencies that are particularly seen in the Korean BD population as compared to European populations. Analysis of epidemiologic trends over the past three decades in Korea shows a decreasing prevalence of complete BD and a higher prevalence of intestinal BD. We also discuss the ever-evolving understanding of the pathogenesis of BD, noting the complex interplay among genetics, environment, and immunology. The HLA-B51 allele is the most significant known genetic risk factor in developing BD. We also discuss more recently studied associations between BD and immune factors such as IL-10, IL-23R-IL-12RB2, IL-1A-IL-1B, CCR1, ERAP1, and the GIMAP cluster, the last of which has been found to have an association with BD specifically in Korea. Environmental factors such as pollution and microbials are often the inciting event in developing BD, as they trigger an imbalanced immune response in genetically susceptible individuals, one that has been often found to exhibit an aberrant Th1/Th17 response. There would be value to further studying the pathogenesis and clinical characteristics of Korean BD.
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참고문헌 (67)
참고문헌 신청
Joo CR / 1961 / Two cases of Behçet’s syndrome / J Cathol Med Coll 5:393~400
Kim D / 1962 / Behcet’s syndrome : a report of four cases including one with extreme systemic manifestations / J Korean Med Assoc 5:52~58
Bang D / 2011 / Behçet’s disease / Paper presented at:22nd World Congress of Dermatology
Bang D / 2013 / Behçet’s disease in Korea / Hanuri Publishing Co
International Society for Behçet’s Disease / 2000 / 8-9th International Conference on Behçet’s Disease / Design Mecca Publishing Co
Kim D / 1962 / Behcet’s syndrome : a report of four cases including one with extreme systemic manifestations / J Korean Med Assoc 5:52~58
Bang D / 2011 / Behçet’s disease / Paper presented at:22nd World Congress of Dermatology
Bang D / 2013 / Behçet’s disease in Korea / Hanuri Publishing Co
International Society for Behçet’s Disease / 2000 / 8-9th International Conference on Behçet’s Disease / Design Mecca Publishing Co
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