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논문 기본 정보

자료유형
학술저널
저자정보
Apurba Ghosh (Institute of Child Health Kolkata) Balasubramaniam Sundaram (Kanchi Kamakoti Childs Trust Hospital) Piyali Bhattacharya (Sanjay Gandhi Post Graduate Institute of Medical Science) Nimain Mohanty (MGM Medical College) Nirmala Dheivamani (Institute of Child Health Chennai) Sushant Mane (Grant Govt. Medical College & Sir J.J. Group of Hospitals) Bhaswati Acharyya (Institute of Child Health Kolkata) Vijay Kamale (MGM Medical College) Sumon Poddar (Institute of Child Health Kolkata) Akash Khobragade (Grant Govt. Medical College & Sir J.J. Group of Hospitals) Winston Thomas (Institute of Child Health Chennai) Sumant Prabhudesai (Kanchi Kamakoti Childs Trust Hospital) Ankita Choudhary (MGM Medical College) Monjori Mitra (Institute of Child Health Kolkata)
저널정보
대한소아소화기영양학회 Pediatric Gastroenterology, Hepatology & Nutrition Pediatric Gastroenterology, Hepatology & Nutrition 제24권 제5호
발행연도
2021.9
수록면
423 - 431 (9page)
DOI
10.5223/pghn.2021.24.5.423

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Purpose: To assess the effect of combination probiotic Saccharomyces boulardii CNCM-I 3799 and Bacillus subtilis CU-1 in outpatient management of acute watery diarrhea in children. Methods: A randomized double-blind placebo-controlled study was conducted in 180 participants aged six months to five years with acute mild to moderate diarrhea. All were enrolled from six centers across India and centrally randomized to receive S. boulardii CNCM-I 3799 and B. subtilis CU-1 or a placebo along with oral rehydration salts and zinc supplementation. Each participant was followed up for three months to assess recurrence of diarrhea. Results: The mean duration of diarrhea in the probiotic and placebo groups were 54.16 hours and 59.48 hours, respectively. The difference in the duration of diarrhea in those administered with probiotic or placebo within 24 hours of diarrhea onset was 25.21 hours. Furthermore, the difference in duration of diarrhea was 13.84 hours (p<0.05) for participants who were administered with probiotics within 48 hours. There were no significant differences in the stool frequencies between the two arms. After three months, 15% in the probiotic group and 18.5% in the placebo group reported episodes of diarrhea. The mean duration of diarrhea was considerably lower in the probiotic group, 31.02 hours versus 48 hours in placebo (p=0.017). Conclusion: S. boulardii CNCM-I 3799 and B. subtilis CU-1 combination was effective in reducing the duration of diarrhea when administered within 48 hours of diarrhea onset. Similarly, it reduced recurrence of diarrhea and its intensity in the subsequent three months.
#Acute gastroenteritis #Diarrhea duration #Multi-strain probiotic #Saccharomyces boulardii #Bacillus subtilis #Stool frequency

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참고문헌 (18)

참고문헌 신청
Guarino A / 2015 / Probiotics for prevention and treatment of diarrhea / J Clin Gastroenterol 49(Suppl 1):S37~S45 google schola Szajewska H / 2014 / Use of probiotics for management of acute gastroenteritis : a position paper by the ESPGHAN Working Group for Probiotics and Prebiotics / J Pediatr Gastroenterol Nutr 58:531~539 google schola Guarino A / 2012 / The management of acute diarrhea in children in developed and developing areas : from evidence base to clinical practice / Expert Opin Pharmacother 13:17~26 google schola Billoo AG / 2016 / Role of a probiotic(Saccharomyces boulardii)in management and prevention of diarrhoea / World J Gastroenterol 12:4557~4560 google schola Villarruel G / 2007 / placebo-controlled study / Acta Paediatr 96:538~541 google schola

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