Association of High Expression of Mitochondrial Fission Regulator 2 with Poor Survival of Patients with Esophageal Squamous Cell Carcinoma

Hongwei Li; Xingzhuang Zhu; Wei Zhang; Wenjie Lu; Chuan Liu; Jinbo Ma; Rukun Zang; Yipeng Song

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자료유형: 학술저널

저자정보: Hongwei Li (Yantai Yuhuangding Hospital Qingdao University) Xingzhuang Zhu (Yantai Yuhuangding Hospital Qingdao University) Wei Zhang (Yantai Yuhuangding Hospital Qingdao University) Wenjie Lu (Yantai Yuhuangding Hospital Qingdao University) Chuan Liu (The First Affiliated Hospital of Chongqing Medical University) Jinbo Ma (Yantai Yuhuangding Hospital Qingdao University) Rukun Zang (Yantai Yuhuangding Hospital Qingdao University) Yipeng Song (Yantai Yuhuangding Hospital Qingdao University)

저널정보: 대한암예방학회 대한암예방학회지 대한암예방학회지 제26권 제4호

발행연도: 2021.12

수록면: 250 - 257 (8page)

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Mitochondrial fission regulator 2 (MTFR2) is associated with mitochondrial fission, while few studies have assessed the associ ations between MTFR2 expression and clinical characteristics or prognosis of esophageal squamous cell carcinoma (ESCC). In this study, we compared the expression of MTFR2 in 6 ESCC tumors and relative normal tissues by immunohistochemistry (IHC). To assess the effect of MTFR2 expression on clinicopathologic characteristics and survival, 115 paraffin embedded ESCC tissue samples were assessed by IHC staining. Furthermore, the association between clinicopathological properties and MTFR2 expres sion in patients with ESCC was examined. The survival analysis was performed using the Cox regression models. We found that MTFR2 expression was significantly increased in ESCC tumors compared with normal esophageal epithelial cells. IHC analysis of 115 paraffin embedded ESCC tumor specimens of the patients showed that the expression of MTFR2 was significantly associated with clinical stage (P < 0.001), tumor classification (P < 0.001), histological grade (P < 0.001), and other clinicopathological char acteristics. Both univariate and multivariate analyses showed that MTFR2 expression was inversely correlated with the survival of ESCC patients. In conclusion, the expression of MTFR2 is significantly associated with clinicopathologic characteristics and prog nosis of ESCC. Thus, MTFR2 expression could serve as a potentially important prognostic biomarker and clinical target for patients with ESCC. Key Words MTFR2, Esophageal squamous cell carcinoma, Immunohistochemistry, Prognosis

#MTFR2 #Esophageal squamous cell carcinoma #Immunohistochemistry #Prognosis

참고문헌 (29)

참고문헌 신청

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