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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.7
- 수록면
- 383 - 391 (9page)
- DOI
- https://doi.org/10.4306/pi.2017.14.4.383
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초록· 키워드
오류제보하기
Schizophrenia is a chronic and debilitating mental disorder. The persisting negative and cognitive symptoms that are unresponsive to pharmacotherapy reveal the impairment of neuroprotective aspects of schizophrenia. In this review, of the several neuroprotective factors, we mainly focused on neuroinflammation, neurogenesis, and oxidative stress. We conducted a narrative and selective review. Neuroinflammation is mainly mediated by pro-inflammatory cytokines and microglia. Unlike peripheral inflammatory responses, neuroinflammation has a role in various neuronal activities such as neurotransmission neurogenesis. The cross-talk between neuroinflammation and neurogenesis usually has beneficial effects in the CNS under physiological conditions. However, uncontrolled and chronic neuroinflammation exert detrimental effects such as neuronal loss, inhibited neurogenesis, and excessive oxidative stress. Neurogenesis is also a major component of neuroprotection. Adult neurogenesis mainly occurs in the hippocampal region, which has an important role in memory formation and processing. Impaired neurogenesis and an ineffective response to antipsychotics may be thought to indicate a deteriorating course of schizophrenia. Oxidative stress and excessive dopaminergic neurotransmission may create a vicious cycle and consequently disturb NMDA receptor-mediated glutamatergic neurotransmission. Based on the current evidences, several neuroprotective therapeutic approaches have been reported to be efficacious for improving psychopathology, but further longitudinal and large-sample based studies are needed.
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등록된 정보가 없습니다.
참고문헌 (140)
참고문헌 신청
Lieberman JA / 2006 / Preventing clinical deterioration in the course of schizophrenia : the potential for neuroprotection / J Clin Psychiatry 67:983~990
Perala J / 2007 / Lifetime prevalence of psychotic and bipolar I disorders in a general population / Arch Gen Psychiatry 64:19~28
Monteiro LC / 2008 / Insight, cognitive dysfunction and symptomatology in schizophrenia / Eur Arch Psychiatry Clin Neurosci 258:402~405
Ibrahim HM / 2012 / Treatment of cognitive dysfunction in schizophrenia / Curr Pharm Biotechnol 13:1587~1594
Hanson E / 2010 / Assessment of pharmacotherapy for negative symptoms of schizophrenia / Curr Psychiatry Rep 12:563~571
Perala J / 2007 / Lifetime prevalence of psychotic and bipolar I disorders in a general population / Arch Gen Psychiatry 64:19~28
Monteiro LC / 2008 / Insight, cognitive dysfunction and symptomatology in schizophrenia / Eur Arch Psychiatry Clin Neurosci 258:402~405
Ibrahim HM / 2012 / Treatment of cognitive dysfunction in schizophrenia / Curr Pharm Biotechnol 13:1587~1594
Hanson E / 2010 / Assessment of pharmacotherapy for negative symptoms of schizophrenia / Curr Psychiatry Rep 12:563~571
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