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지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.12
- 수록면
- 368 - 378 (11page)
- DOI
- 10.5230/jgc.2018.18.e36
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초록· 키워드
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Purpose: Fibrinogen and platelets have been reported to play important roles in tumorigenesis and cancer progression. The aim of this research was to investigate the combination of functions of fibrinogen, platelets, and mean platelet volume (MPV) in predicting the survival of patients with gastric cancer (GC).
Materials and Methods: A retrospective study was conducted with 1,946 patients with GC and 299 patients with benign gastric tumor to analyze their fibrinogen, platelet, and MPV levels, and other clinicopathological characteristics along with their prognoses. Several indicators were evaluated along with fibrinogen, platelets, and MPV and their prognostic abilities were assessed. Univariate and multivariate survival analyses were conducted to determine the independent risk factors for overall survival.
Results: Increased levels of fibrinogen, platelets, and MPV were observed with the progress of the GC stages. Elevated fibrinogen, platelets, and the combined indicators, including fibrinogen*MPV (FM), platelet*fibrinogen*MPV (PFM), fibrinogen/MPV (FMR), platelet*fibrinogen (PF), platelet*fibrinogen/MPV (PFMR), platelet*MPV (PM), and platelet/ MPV (PMR), foreboded poor prognosis. Meanwhile fibrinogen and FMR can be considered as independent risk factors for overall survival in patients with non-metastatic GC. But these indicators can hardly predict survival of patients in stage IV.
Conclusions: Elevated fibrinogen, platelets, and MPV levels were in accordance with advanced stages, and fibrinogen, platelet, and MPV, in combination, can be used to predict survival of patients with non-metastatic GC. FMR was an independent prognostic factor for overall survival of patients with GC.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Siegel RL / 2016 / Cancer statistics / CA Cancer J Clin 66:7~30
Chen W / 2016 / Cancer statistics in China, 2015 / CA Cancer J Clin 66:115~132
Wang WH / 2003 / Non-steroidal anti-inflammatory drug use and the risk of gastric cancer: a systematic review and meta-analysis / J Natl Cancer Inst 95:1784~1791
Mroczko B / 2009 / Pre-treatment serum and plasma levels of matrix metalloproteinase 9 (MMP-9) and tissue inhibitor of matrix metalloproteinases 1 (TIMP-1) in gastric cancer patients / Clin Chem Lab Med 47:1133~1139
Zheng S / 2009 / Platelets and fibrinogen facilitate each other in protecting tumor cells from natural killer cytotoxicity / Cancer Sci 100:859~865
Chen W / 2016 / Cancer statistics in China, 2015 / CA Cancer J Clin 66:115~132
Wang WH / 2003 / Non-steroidal anti-inflammatory drug use and the risk of gastric cancer: a systematic review and meta-analysis / J Natl Cancer Inst 95:1784~1791
Mroczko B / 2009 / Pre-treatment serum and plasma levels of matrix metalloproteinase 9 (MMP-9) and tissue inhibitor of matrix metalloproteinases 1 (TIMP-1) in gastric cancer patients / Clin Chem Lab Med 47:1133~1139
Zheng S / 2009 / Platelets and fibrinogen facilitate each other in protecting tumor cells from natural killer cytotoxicity / Cancer Sci 100:859~865
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