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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Objective: A neuropsychological battery is a gold standard for thorough cognitive evaluation. However, it could not be used as a screening test due to its long inspection time and high cost. This study is conducted to identify specific cognitive subdomains that alter even at the early stage of cognitive decline.
Methods: Neuropsychological battery results of 575 persons who visited memory clinic were analysed. We classified stages of cognitive decline according to Clinical Dementia Rating (CDR) and CDR-Sum of boxes (CDR-SB). To explore which subdomains can sensitively distinguish normal cognition from the early cognitive impairment, we used Variable Importance in Projection (VIP) in addition to analysis of covariance.
Results: We found that scores in subdomain tests such as Rey Complex Figure Test immediate and delayed recall successfully differentiate persons with CDR 0 from those with CDR 0.5 and also persons with CDR-SB 0 from those with CDR-SB 0.5 as indicated by VIP values greater than 1.
Conclusion: These results suggest that alterations in visuospatial memory function might be a sensitive sign reflecting the early cognitive decline. The combination of only a few subtests could be also used as a reliable and sensitive screening tool to detect early cognitive impairment.
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등록된 정보가 없습니다.
참고문헌 (36)
참고문헌 신청
Lee JS / 2021 / Korean Dementia Observatory 2020 :74
Tábuas-Pereira M / 2016 / Prognosis of early-onset vs. late-onset mild cognitive impairment: comparison of conversion rates and its predictors / Geriatrics(Basel) 1:11
Jorm AF / 2005 / Projections of future numbers of dementia cases in Australia with and without prevention / Aust N Z J Psychiatry 39:959~963
Yu SY / 2015 / Cost-effectiveness of nationwide opportunistic screening program for dementia in South Korea / J Alzheimers Dis 44:195~204
Ismail Z / 2010 / Brief cognitive screening instruments : an update / Int J Geriatr Psychiatry 25:111~120
Tábuas-Pereira M / 2016 / Prognosis of early-onset vs. late-onset mild cognitive impairment: comparison of conversion rates and its predictors / Geriatrics(Basel) 1:11
Jorm AF / 2005 / Projections of future numbers of dementia cases in Australia with and without prevention / Aust N Z J Psychiatry 39:959~963
Yu SY / 2015 / Cost-effectiveness of nationwide opportunistic screening program for dementia in South Korea / J Alzheimers Dis 44:195~204
Ismail Z / 2010 / Brief cognitive screening instruments : an update / Int J Geriatr Psychiatry 25:111~120
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