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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한백신학회 Clinical and Experimental Vaccine Research Clinical and Experimental Vaccine Research Vol.10 No.3
- 발행연도
- 2021.9
- 수록면
- 252 - 258 (7page)
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초록· 키워드
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Purpose: Virus-like particles (VLPs) are being developed as a promising vaccine platform and therapeutic delivery. Various strategies for effectively constructing VLPs have been studied, but relatively few studies have been done on various factors affecting storage. In this study, we investigated the antigenic changes of VLPs in an acidic or basic pH environment using influenza VLPs as an experimental model.
Materials and Methods: Influenza VLPs containing hemagglutination and M1 proteins were generated and their antigenicity and protective immunity in vitro and in vivo were evaluated after exposure to acidic (pH 4 and 5) or basic (pH 9 and 10) pH buffers.
Results: VLP exposed to basic pH showed similar levels of antigenicity to those stored in neutral pH, while antigenicity of VLP exposed to acidic pH was found to be significantly reduced compared to those expose neutral or basic pH. All groups of mice responded effectively to low concentrations of virus infections; however, VLP vaccine groups exposed to acid pH were found not to induce sufficient protective immune responses when a high concentration of influenza virus infection.
Conclusion: In order for VLP to be used as a more powerful vaccine platform, it should be developed in a strategic way to respond well to external changes such as acidic pH conditions.
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참고문헌 (26)
참고문헌 신청
Perez Rubio A / 2018 / Cell culture-derived flu vaccine : present and future / Hum Vaccin Immunother 14:1874~1882
Woo EJ / 2017 / Postmarketing safety surveillance of trivalent recombinant influenza vaccine : reports to the Vaccine Adverse Event Reporting System / Vaccine 35:5618~5621
Bright RA / 2007 / Influenza virus-like particles elicit broader immune responses than whole virion inactivated influenza virus or recombinant hemagglutinin / Vaccine 25:3871~3878
Buckland B / 2014 / Technology transfer and scale-up of the Flublok recombinant hemagglutinin(HA)influenza vaccine manufacturing process / Vaccine 32:5496~5502
Liu YV / 2015 / Recombinant virus-like particles elicit protective immunity against avian influenza A(H7N9)virus infection in ferrets / Vaccine 33:2152~2158
Woo EJ / 2017 / Postmarketing safety surveillance of trivalent recombinant influenza vaccine : reports to the Vaccine Adverse Event Reporting System / Vaccine 35:5618~5621
Bright RA / 2007 / Influenza virus-like particles elicit broader immune responses than whole virion inactivated influenza virus or recombinant hemagglutinin / Vaccine 25:3871~3878
Buckland B / 2014 / Technology transfer and scale-up of the Flublok recombinant hemagglutinin(HA)influenza vaccine manufacturing process / Vaccine 32:5496~5502
Liu YV / 2015 / Recombinant virus-like particles elicit protective immunity against avian influenza A(H7N9)virus infection in ferrets / Vaccine 33:2152~2158
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