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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 428 - 442 (15page)
- DOI
- 10.4048/jbc.2021.24.e42
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초록· 키워드
오류제보하기
Purpose Triple-negative breast cancer (TNBC) is a subtype of breast cancer. Increasing evidence supports that dysregulation of long noncoding RNAs (lncRNAs) plays a vital role in cancer progression. RNA component of mitochondrial RNA processing endoribonuclease (RMRP), a lncRNA, is characterized as a tumor-propeller in some cancers, but its mechanism in TNBC remains poorly understood. This study aimed to determine whether and how RMRP functions in TNBC.
Methods Cell proliferation was determined by cell counting kit-8 (CCK-8) and colony formation assays and cell apoptosis by flow cytometry analysis and terminal deoxynucleotidyl transferase-mediated nick end labeling (TUNEL) assay. Cell migration and invasion were determined by transwell assays. RNA-binding protein immunoprecipitation (RIP), luciferase reporter, and RNA pulldown assays were implemented to assess the interaction of RMRP with other molecules in TNBC cells.
Results RMRP expression was elevated in TNBC cells. RMRP knockdown repressed cell proliferation, migration, and invasion, but induced apoptosis in TNBC. In addition, RMRP was found to target microRNA-766-5p (miR-766-5p) in TNBC cells. Silencing miR-766-5p enhanced cell viability and decreased apoptosis, whereas miR-766-5p overexpression had opposite effects. Furthermore, miR-766-5p was found to bind to yes-associated protein 1 (YAP1). Moreover, miR-766-5p inhibition reversed the repressive effect of RMRP knockdown on the malignant progression of TNBC.
Conclusion The present study manifested that RMRP promotes the growth, migration, and invasion of TNBC cells via the miR-766-5p/YAP1 axis. These findings provide novel perspectives for TNBC treatment.
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참고문헌 (30)
참고문헌 신청
Tang L / 2020 / Long noncoding RNA DCST1-AS1 promotes cell proliferation and metastasis in triple-negative breast cancer by forming a positive regulatory loop with miR-873-5p and MYC / J Cancer 11:311~323
Peart O / 2015 / Breast intervention and breast cancer treatment options / Radiol Technol 86:535M~558M
Hwang SY / 2019 / Recent therapeutic trends and promising targets in triple negative breast cancer / Pharmacol Ther 199:30~57
Barton M / 2019 / BC200 overexpression contributes to luminal and triple negative breast cancer pathogenesis / BMC Cancer 19:994
Zhang M / 2017 / lncRNA NEAT1 is closely related with progression of breast cancer via promoting proliferation and EMT / Eur Rev Med Pharmacol Sci 21:1020~1026
Peart O / 2015 / Breast intervention and breast cancer treatment options / Radiol Technol 86:535M~558M
Hwang SY / 2019 / Recent therapeutic trends and promising targets in triple negative breast cancer / Pharmacol Ther 199:30~57
Barton M / 2019 / BC200 overexpression contributes to luminal and triple negative breast cancer pathogenesis / BMC Cancer 19:994
Zhang M / 2017 / lncRNA NEAT1 is closely related with progression of breast cancer via promoting proliferation and EMT / Eur Rev Med Pharmacol Sci 21:1020~1026
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