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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.11
- 수록면
- 777 - 782 (6page)
- DOI
- http://dx.doi.org/10.14348/molcells.2016.0232
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초록· 키워드
오류제보하기
The innate immune system has evolved to detect and destroy invading pathogens before they can establish systemic infection. To successfully eradicate pathogens, including viruses, host innate immunity is activated through diverse pattern recognition receptors (PRRs) which detect conserved viral signatures and trigger the production of type I interferon (IFN) and pro-inflammatory cytokines to mediate viral clearance. Viral persistence requires that viruses co-opt cellular pathways and activities for their benefit. In particular, due to the potent antiviral activities of IFN and cytokines, viruses have developed various strategies to meticulously modulate intracellular innate immune sensing mechanisms to facilitate efficient viral replication and persistence. In this review, we highlight recent advances in the study of viral immune evasion strategies with a specific focus on how Kaposi’s sarcoma-associated herpesvirus (KSHV) effectively targets host PRR signaling pathways.
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등록된 정보가 없습니다.
참고문헌 (76)
참고문헌 신청
Abend, J. R. / 2012 / Kaposi's sarcomaassociated herpesvirus microRNAs target IRAK1 and MYD88, two components of the toll-like receptor/interleukin-1R signaling cascade, to reduce inflammatory-cytokine expression / J. Virol 86:11663~11674
Ablasser, A. / 2013 / cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING / Nature 498:380~384
Ahmad, H. / 2011 / Kaposi sarcoma-associated herpesvirus degrades cellular Toll-interleukin-1 receptor domaincontaining adaptor-inducing beta-interferon(TRIF) / J. Biol. Chem 286:7865~7872
Akira, S. / 2006 / Pathogen recognition and innate immunity / Cell 124:783~801
Ansari, M. A. / 2015 / Herpesvirus genome recognition induced acetylation of nuclear IFI16 is essential for its cytoplasmic translocation, inflammasome and IFN-beta responses. PLoS Pathog. 11 / PLoS Pathog 11:e1005019
Ablasser, A. / 2013 / cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING / Nature 498:380~384
Ahmad, H. / 2011 / Kaposi sarcoma-associated herpesvirus degrades cellular Toll-interleukin-1 receptor domaincontaining adaptor-inducing beta-interferon(TRIF) / J. Biol. Chem 286:7865~7872
Akira, S. / 2006 / Pathogen recognition and innate immunity / Cell 124:783~801
Ansari, M. A. / 2015 / Herpesvirus genome recognition induced acetylation of nuclear IFI16 is essential for its cytoplasmic translocation, inflammasome and IFN-beta responses. PLoS Pathog. 11 / PLoS Pathog 11:e1005019
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