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논문 기본 정보

자료유형
학술저널
저자정보
Avery Rui Sun (Department of Biomedical Engineering Southern University of Science and Technology) Qili Sun (Department of Biomedical Engineering Southern University of Science and Technology) Yansong Wang (Department of Biomedical Engineering Southern University of Science and Technology) Liqiu Hu (Department of Biomedical Engineering Southern University of Science and Technology) Yutong Wu (Department of Biomedical Engineering Southern University of Science and Technology) Fenbo Ma (Department of Biomedical Engineering Southern University of Science and Technology) Jiayi Liu (Department of Biomedical Engineering Southern University of Science and Technology) Xiangchao Pang (Department of Biomedical Engineering Southern University of Science and Technology) Bin Tang (Department of Biomedical Engineering Southern University of Science and Technology)
저널정보
한국생체재료학회 생체재료학회지 생체재료학회지 제27권
발행연도
2023.3
수록면
724 - 755 (32page)
DOI
https://doi.org/10.1186/s40824-023-00361-2

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Background : Titanium (Ti) is now widely used as implant material due to its excellent mechanical properties and superior biocompatibilities, while its inert bioactivities might lead to insufficient osseointegration, and limit its performance in dental applications. Methods : We introduced a robust and simple approach of modifying titanium surfaces with polysaccharide complexes. Titanium samples were subjected to hydrothermal treatment to create a uniform porous structure on the surface, followed by coating with a bioinspired and self-assembly polydopamine layer. Strontium Eucommia Ulmoides Polysaccharide (EUP-Sr) complexes are then introduced to the polydopamine-coated porous titanium. Multiple morphological and physiochemical characterizations are employed for material evaluation, while cell proliferation and gene expression tests using macrophages, primary alveolar bone osteoblasts, and vascular endothelial cells are used to provide an overall insight into the functions of the product. The significances of statistical differences were analyzed using student’s t-test. Results : Microscopic and spectrometric characterizations confirmed that the Ti surface formed a porous structure with an adequate amount of EUP-Sr loading. The attachment was attributed to hydrogen bonding between the ubiquitous glycosidic linkage of the polysaccharide complex and the ring structure of polydopamine, yet the loaded EUP-Sr complex can be gradually released, consequently benefiting the neighboring microenvironment. Cell experiments showed no cytotoxicity of the material, and the product showed promising anti-inflammation, osseointegration, and angiogenesis properties, which were further confirmed by in vivo evaluations. Conclusion : We believe the EUP-Sr modified titanium implant is a promising candidate to be used in dental applications with notable osteoimmunomodulation and angiogenesis functions. And the novel technique proposed in this study would benefit the modification of metal/inorganic surfaces with polysaccharides for future research.

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