Clinical Efficacy and Safety of Endoscopic Treatment of Gastrointestinal Stromal Tumors in the Stomach

Joo Moon Kyung; Park Jong-Jae; Lee Yeon Ho; Lee Beom Jae; Kim Seong Min; Kim Won Shik; Yoo Ah Young; Chun Hoon Jai; Lee Sang Woo

doi:10.5009/gnl210454

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자료유형: 학술저널

저자정보: Joo Moon Kyung (Division of Gastroenterology Department of Internal Medicine Korea University Guro Hospital Korea University College of Medicine Seoul Korea) Park Jong-Jae (Division of Gastroenterology Department of Internal Medicine Korea University Guro Hospital Korea University College of Medicine Seoul Korea) Lee Yeon Ho (Division of Gastroenterology Department of Internal Medicine Korea University Guro Hospital Korea University College of Medicine Seoul Korea) Lee Beom Jae (Division of Gastroenterology Department of Internal Medicine Korea University Guro Hospital Korea University College of Medicine Seoul Korea) Kim Seong Min (Division of Gastroenterology Department of Internal Medicine Korea University Guro Hospital Korea University College of Medicine Seoul Korea) Kim Won Shik (Division of Gastroenterology Department of Internal Medicine Korea University Guro Hospital Korea University College of Medicine Seoul Korea) Yoo Ah Young (Division of Gastroenterology Department of Internal Medicine Korea University Guro Hospital Korea University College of Medicine Seoul Korea) Chun Hoon Jai (Division of Gastroenterology Department of Internal Medicine Korea University Anam Hospital Korea University College of Medicine Seoul Korea) Lee Sang Woo (Division of Gastroenterology Department of Internal Medicine Korea University Ansan Hospital Korea University College of Medicine Ansan Korea)

저널정보: 거트앤리버 발행위원회 Gut and Liver Gut and Liver 제17권 제2호

발행연도: 2023.3

수록면: 217 - 225 (9page)

DOI: 10.5009/gnl210454

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Background/Aims: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors in the stomach. We evaluated the clinical outcomes of endoscopic treatment for gastric GISTs. Methods: This is a single center, retrospective study that enrolled 135 cases of gastric subepithelial tumors (SETs) resected by endoscopic procedures and confirmed as GISTs by histopathology from March 2005 to July 2019. The immediate and long-term clinical outcomes were analyzed retrospectively. Results: The mean patient age was 57.9 years, and the mean tumor size was 2.1 cm. Of the tumors, 43.0% were located in the body, followed by the fundus (26.7%) and cardia (17.0%). Most tumors (85.2%) were resected by endoscopic submucosal dissection, followed by endoscopic mucosal resection (6.7%), submucosal tunneling endoscopic resection (5.9%), and endoscopic full-thickness resection (2.2%). Macroperforation occurred in 4.4% and microperforation in 6.7% of the cases. The R0 resection rate was 15.6%. However, the rate of complete resection by the endoscopic view was 90.4%, of which 54.8% of cases were in the very-low-risk group, followed by the low-risk group (28.1%), intermediate-risk group (11.9%), and high-risk group (5.2%). During 36.5 months of follow-up, recurrence was found in four (3.4%) of the 118 patients who were monitored for more than 6 months (low-risk group, 1/37 [2.7%]; intermediate-risk group, 2/11 [18.2%]; high-risk group, 1/6 [16.7%]). Conclusions: Endoscopic treatment of a GIST appears to be a feasible procedure in selected cases. However, additional surgery should be considered if the pathologic results correspond to intermediate- or high-risk groups.

#Gastrointestinal stromal tumors #Endoscopy #Recurrence

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