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논문 기본 정보

자료유형
학술저널
저자정보
Ram Prakash Sah (Department of Anatomy, JSS Medical College, JSS Academy of Higher Education and Research, Mysore, India) C. S. Vidya (Department of Anatomy, JSS Medical College, JSS Academy of Higher Education and Research, Mysore, India) Pratibha Pereira (Department of Geriatric Medicine, JSS Hospital, JSS Academy of Higher Education and Research, Mysore, India) Shubha Jayaram (Department of Biochemistry, Mysore Medical College and Research Institute, Mysore, India) Anshu Kumar Yadav (Department of Biochemistry and Medical Genetics, JSS Medical College, JSS Academy of Higher Education and Research, Mysore, India) P. Sujatha (Department of Biochemistry, JSS Medical College, JSS Academy of Higher Education and Research, Mysore, India)
저널정보
대한노인병학회 Annals of geriatric medicine and research Annals of geriatric medicine and research Vol.28 No.1
발행연도
2024.3
수록면
116 - 120 (5page)
DOI
10.4235/agmr.23.0135

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Alzheimer disease (AD) is the most common cause of dementia worldwide. Its clinical manifestations include a progressive loss of memory and other cognitive domains, as well as brain atrophy. An elevated homocysteine level (>15 µmol/L), known as hyperhomocysteinemia, is also an attributing risk factor for AD, vascular pathologies, and brain atrophy. Neuroimaging studies including T2-weighted magnetic resonance imaging scans revealed white matter hyperintensities in the periventricular and deep white matter, enlarged ventricles, widened sulci, and decreased white matter mass, which are features of aging, as well as cerebrovascular changes. This case series investigated changes in biochemical marker levels including serum homocysteine, folate, and vitamin B12, and the degree of atrophic variations in cortical-subcortical white matter in AD. The present study hypothesized that serum homocysteine levels might be used as a surrogate marker to screen for AD at an earlier stage.

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