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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.9
- 수록면
- 160 - 166 (7page)
- DOI
- 10.22889/KJP.2024.55.3.160
이용수
초록· 키워드
오류제보하기
Bletilla striata Reichenbach, a member of the Orchidaceae family has traditionally been used for wound healing, hemostasis, and reducing swelling due to its astringent properties. In this study, the 70% ethanol extract of B. striata tubers significantly reduced okadaic acid-induced tau hyperphosphorylation in HT22 cells, as determined by western blot analysis. Tau hyperphosphorylation is considered one of major contributors to Alzheimer" disease. The dichloromethane-partitioned fraction of the B. striata extract, which exhibited the strongest activity, was subjected to bioassay-guided isolation using various column chromatography techniques. This process led to the isolation and identification of three compounds: 3,7-dihydroxy-2,4-dimethoxyphenanthrene (1), coelonin (2) and 4-hydroxybenzyl-4,7-dimethoxy-9,10-dihydrophenanthrene-2-ol (3). All three compounds reduced tau hyperphosphorylation in a dose-dependent manner without exhibiting cytotoxicity. Notably, 4-hydroxybenzyl-4,7-dimethoxy-9,10-dihydrophenanthrene-2-ol (3) at 15 μg/mL significantly reduced tau hyperphosphorylation to 60% of the levels observed in the okadaic acid-only treated control group. These results suggest that B. striata extract and its active compounds may offer potential therapeutic benefits against Alzheimer’s disease by inhibiting tau hyperphosphorylation.
목차
Abstract
재료 및 방법
결과 및 고찰
결론
인용문헌
참고문헌 (22)
참고문헌 신청
Mishra, S. (2016) Does modern medicine increase life expectancy: Quest for the Moon Rabbit? Indian Heart J. 68: 19-27.
De Magalhães, J. P., Stevens, M. and Thornton, D. (2017) The business of anti-aging science. Trends Biotechnol. 35: 1062-1073.
Andrade, S., Nunes, D., Dabur, M., Ramalho, M. J., Pereira, M. C. and Loureiro, J. A. (2023) Therapeutic potential of natural compounds in neurodegenerative diseases: insights from clinical trials. Pharmaceutics 15: 212.
Lopez, J. A. S., Gonzalez, H. M. and Leger, G. C. (2019) Alzheimer’s disease. Handb. Clin. Neurol. 167: 231-255.
Ashrafian, H., Zadeh, E. H. and Khan, R. H. (2021) Review on Alzheimer’s disease: inhibition of amyloid beta and tau tangle formation. Int. J. Biol. Macromol. 167: 382-394.
De Magalhães, J. P., Stevens, M. and Thornton, D. (2017) The business of anti-aging science. Trends Biotechnol. 35: 1062-1073.
Andrade, S., Nunes, D., Dabur, M., Ramalho, M. J., Pereira, M. C. and Loureiro, J. A. (2023) Therapeutic potential of natural compounds in neurodegenerative diseases: insights from clinical trials. Pharmaceutics 15: 212.
Lopez, J. A. S., Gonzalez, H. M. and Leger, G. C. (2019) Alzheimer’s disease. Handb. Clin. Neurol. 167: 231-255.
Ashrafian, H., Zadeh, E. H. and Khan, R. H. (2021) Review on Alzheimer’s disease: inhibition of amyloid beta and tau tangle formation. Int. J. Biol. Macromol. 167: 382-394.
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