Abstract
Objective : This study attempted to investigate the effects of a multimodal interventional occupational therapy program(MIOTP) on cognitive function, daily life performance and quality of life in patients with mild Alzheimer''s Disease.

Methods : A randomized control group pretest?posttest design was applied to test the effectiveness of a MIOTP on the subjects of 59 patients with mild AD. The dementia patients recruited in the study were divided into 39 patients in the experimental group and 20 patients in the control group using the simple randomized method. In the experimental group, MIOTP was applied at the same time with the pharmacological treatment, while the control group maintained the pharmacological treatment but not the non-pharmacological intervention. Pre-post test were performed at the 1st and the 10th session, and MIOTP was conducted twice a week for 8 weeks and for 120 minutes per session. In order to evaluate the cognitive function of the subjects, MMSE-DS and COSAS were used, and K-IADL was used to measure activities of daily living (ADL) and QOL-AD was conducted to measure the quality of life.
Results : From the results of comparing the average of variations within the group, MMSE-DS, COSAS, K-IADL and QOL-AD scores of the experimental group were significantly improved (p<.01). On the other hand, the MMSE-DS and K-IADL scores of the control group were significantly decreased (p<.01). COSAS and QOL-AD also showed a tendency to decrease, but not statistically significant (p>.05). From the results of comparing the average of variations between the two groups, cognitive function, ADL, and quality of life mean scores were significantly different (p<.01). Also, significant differences were found in the cognitive function sub domains such as orientation (p<.01), concentration (p<.05), visual perception (p<.05) and high cognitive function (p<.01). From the results of measuring the correlation between evaluation tools, the MMSE-DS total score was positively correlated with the COSAS total score (p<.01), and was positively correlated with orientation (p<.05), memory (p<.01), high cognitive function (p<.01) in the COSAS sub domains. The variables that were found to be significant at the correlation between .30 and .45, showing relatively clear correlation.

Conclusions : This study confirmed that the multimodal interventional occupational therapy program(MIOTP) is an effective intervention program for the maintenance and improvement of cognitive function, ADL, and quality of life of dementia patients with mild Alzheimer''s disease. Despite the pharmacological treatment, as cognitive function and ADL of dementia patients are gradually declining, so it is more effective to provide a therapeutic strategy that combines both pharmacological and non-pharmacological treatments. In the future, there is a need to develop a patient?centered group multimodal interventional occupational therapy program(MIOTP), considering the interests and hobbies of patients with medium level as well as mild level dementia patients, and the multimodal interventional occupational therapy program as presented in this study is expected to be actively utilized in the community and clinics.