지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.12
- 수록면
- 465 - 470 (6page)
이용수
초록· 키워드
오류제보하기
Heat shock proteins has molecular chaperone functions in protein biogenesis as well as cytoprotective functions against deleterious environmental stresses. Heat shock proteins (HSP) are classified according to their molecular weight into four general families: HSP110 (110 kDa), HSP90 (84-90 kDa), HSP70 (68-78 kDa) and small heat shock proteins (20-30 kDa). Among these families, mouse HSP25 is expressed in many motor and sensory neurons of the brain stem and spinal cord. However, very little is known about the function of this low molecular weighted heat shock protein in the central nervous system. Recently, it has clearly demonstrated that HSP25 is constitutively expressed in the adult mouse cerebellum by parasagittal bands of Purkinje cells in three distinct regions, the central zone (lobule Ⅵ-Ⅶ) an nodular zone (lobule Ⅸ-Ⅹ), and paraflocculus. Using by immunohistochemistry and western blotting, we investigated the HSP70 and HSP25 expressions after hyperthermic induction and to compared the distribution of HSP70 and HSP25-immunoreactive neruons. In the present study, we observed a little difference between anti-HSP25 and anti-HSP70 immunoreactivity in the cerebellum. Anti-HSP70 immunoreactivity in Purkinje cells showed the time course-varient characteristics in all lobules of cerebellum and cranial nerve Ⅶ motor nuclei and its tract in the brain stem. Moreover, anti-HSP25 immunoreactivity in the brain stem gradually increased by post-heat shock acquisition times. However, cerebellar HSP25 expression was not changed by hyperthermic induction. Immunoblot analysis of protein lysates from controls and hyperthermic mice brains showed a pattern of induction complementary to the immunohistochemical data pattern of expression of HSP70 and HSP25 after hyperthermic induction. This finding means that, in contrast to the expression of HSP25 in brainstem, cerebellar HSP25 expression does not induced by hyperthermic induction.
목차
재료 및 방법
결과
고찰
감사의 글
참고문헌
참고문헌 (27)
참고문헌 신청
1. [학술지(정기간행물)] - Aquino / 1993 / is a major constituent of the central nervous system and is up-regulated only at the mRNA level in acute experimental autoimmune encephalomyelitis : 1340 ~ 1348
2. [학술지(정기간행물)] - Armstrong, C.L / 2000 / Constitutive expression of the 25 kDa heat shock protein HSP25 reveals novel parasagittal bands of Purkinje cells in the adult mouse cerebellar cortex 416 : 383 ~ 397
3. [학술지(정기간행물)] - Armstrong, C.L / 2001 / Constitutive expression of heat shock protein HSP25 in the central nervous system of the developing and adult mouse 434 : 262 ~ 274
4. [학술지(정기간행물)] - Haye / 1994 / Phosphorylation and supramolecular organization of murine small heat shock protein HSP25 abolish its actin polymerization-inhibiting activity : 20780 ~ 200784
5. [학술지(정기간행물)] - Blake / 1990 / In vivo hyperthermia induces expression of HSP70 mRNA in brain regions controlling the neuroendocrine response to stress : 89 ~ 92
2. [학술지(정기간행물)] - Armstrong, C.L / 2000 / Constitutive expression of the 25 kDa heat shock protein HSP25 reveals novel parasagittal bands of Purkinje cells in the adult mouse cerebellar cortex 416 : 383 ~ 397
3. [학술지(정기간행물)] - Armstrong, C.L / 2001 / Constitutive expression of heat shock protein HSP25 in the central nervous system of the developing and adult mouse 434 : 262 ~ 274
4. [학술지(정기간행물)] - Haye / 1994 / Phosphorylation and supramolecular organization of murine small heat shock protein HSP25 abolish its actin polymerization-inhibiting activity : 20780 ~ 200784
5. [학술지(정기간행물)] - Blake / 1990 / In vivo hyperthermia induces expression of HSP70 mRNA in brain regions controlling the neuroendocrine response to stress : 89 ~ 92
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Heat Shock Protein Association with Clinico-Pathological Characteristics of Gastric Cancer in Jordan : HSP70 is Predictive of Poor Prognosis
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Traditional and Novel Mechanisms of Heat Shock Protein 90 (HSP90) Inhibition in Cancer Chemotherapy Including HSP90 Cleavage
Biomolecules & Therapeutics(구 응용약물학회지)
2019 .01
-
열충격단백질 70에 대한 연구
대한물리치료학회지(JKPT)
2000 .01
-
Antibodies to Heat Shock Protein 70kDa and 90kDa in the Patients with Schizophrenia, and Their Relationship with Clinical Variables
생물정신의학
1999 .01
-
Heat Shock Protein 90 (HSP90) and Immune Regulation
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2015 .03
-
Change of Hsp25 Expression in Mouse Cerebellum Induced by Heat Shock
대한체질인류학회 학술대회 연제 초록
2006 .05
-
열충격 단백질의 신경정신의학적 의의와 중요성
생물정신의학
2007 .01
-
신세포암종에서 Heat Shock Protein 27의 발현과 세포자멸사에 대한 연구
Journal of Pathology and Translational Medicine
2006 .01
-
후두 편평 세포암에서의 HSP27 발현에 관한 연구
대한기관식도과학회지
2001 .01
-
급성 뇌경색 환자에서 혈중 Human Heat Shock 단백질 농도 및 항체수준의 상관관계
대한뇌졸중학회지
2005 .01
-
The Prognostic Impact of Heat Shock Proteins Expression in Patients with Esophageal Cancer: A Meta-Analysis
Yonsei Medical Journal
2015 .01
-
Transcriptional responses of heat shock protein 90 (HSP90) and heat shock protein 83 (HSP83) genes by salinity changes in the intertidal crab Macrophthalmus japonicus
환경독성보건학회 심포지엄 및 학술대회
2019 .10
-
Prognostic Significance of Heat Shock Protein 70 Expression in Early Gastric Carcinoma
Journal of Pathology and Translational Medicine
2013 .01
-
아밀로이드 베타에 의한 신경세포 사멸과 이에 대한 열충격 단백질 90의 세포 보호효과
해부·생물인류학
2008 .03
-
[지상 12] Expression of Heat Shock Protein 25 (Hsp25) in the Korean Wild Mice During Cerebellar Development
대한체질인류학회 학술대회 연제 초록
2005 .05
-
내독소로 전처치한 쥐 폐포상피에서 HSP70 유도가 추가 내독소 자극에 따른 IL-6 생성능 및 세포생존도에 미치는 영향
Tuberculosis and Respiratory Diseases
2005 .01
-
대장암종에서 HSP 70의 예후 인자로서의 의의
Annals of Surgical Treatment and Research
2001 .05
-
흰쥐 C6 신경교종 세포에서 Venlafaxine 그리고 Dexamethasone 처리가 열충격 단백질 70의 발현에 미치는 영향
생물정신의학
2005 .01
-
조골세포 세포사멸의 Estrogen 조절에 대한 Hsp27의 영향에 관한 연구
대한구강악안면외과학회지
2004 .01
이 논문의 저자 정보
이 논문과 함께 이용한 논문
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2009-510-016250064