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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.9
- 수록면
- 217 - 227 (11page)
이용수
초록· 키워드
오류제보하기
The present study was set to evaluate the effect of pomegranate extracts on improvement of the menopausal syndromes such as face flushing in ovariectomized rats by carrying out short- and long-term experiments. Pomegranate extracts used to feed rats were prepared from the pulp part which does not contain the rid of the pomegranate, and were dissolved in propylene glycol. From the short-term (16 days) experiment, it was clear that when the 25, 250, 1,250 ㎎/㎏/day concentrations of pomegranate extracts were orally fed to ovariectomized rats, the body temperature of the rats in all the 3 groups were decreased with statistical significance compared to other control groups which were fed with propylene glycol only. Especially, the body temperature decreased by 2.7℃ compared to control groups even when the pomegranate extracts were fed at the low concentration of 25 ㎎/㎏/day implying the usefulness of pomegranate extracts in improving face flushing troubles. In addition, the body weight of the groups fed with pomegranate extracts also decreased when compared to groups fed with only propylene glycol, and the results were also statistically significant. In case of the estradiol level in the blood of rats, the levels were somewhat higher in the groups fed with pomegranate extracts than the control groups, even though the difference was not statistically significant. As found from the results of the short-term experiment, in long-term experiment, the groups fed with pomegranate extracts showed statistically significant decrease in the body temperature and the body weight, whereas the increase of the estradiol levels in blood in each groups were statistically insignificant. During the short- and long-term experiments, no sign of toxicity was found in rats fed with pomegranate extracts indicating no toxic side effects of the pomegranate extracts when orally fed. The concentrations of pomegranate extracts 25, 250, 1250 ㎎/㎏/day treated to ovariectomized rats in this study can be estimated to be 1.5, 15, and 75 g/day when treated to women whose body weight is 60 kg which is average for women with menopausal syndromes. Since even the 75 g/day of high concentration of pomegranate extracts did not show any toxicity in short- and long-term experiments, taking 1.5 g/day concentration of pomegranate extracts would be safe dose for not causing any side effects. Therefore, it can be concluded from the results of this study that taking 1.5 g/day of pomegranate extracts for certain period time will improve the menopausal syndromes including face flushing.
목차
서론
재료 및 방법
결과
고찰
REFERENCES
참고문헌 (31)
참고문헌 신청
1. [학술지(정기간행물)] - Abe T / 1993 / Estrogen does not restore bone lost after ovariectomy in the rat / J Bone Miner Res 8 : 831 ~ 838
2. [학술지(정기간행물)] - Aitken JM / 1972 / Osteoporosis after oophorectomy in the mature female rat and the effect of oestrogen and-or progestogen replacement therapy in its prevention / J Endocrinol 55 : 79 ~ 87
3. [학술지(정기간행물)] - Albertazzi / 1999 / Dietary soy supplementation and phytoestrogen levels / Obstetrics Gynecol 94 : 229 ~ 231
4. [학술지(정기간행물)] - Aviram M / 2000 / Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL and platelet aggregation: studies in humans and in atherosclerotic apolipoprotein E-deficient mice / Am J Clin Natr 71 : 1062 ~ 1076
5. [학술지(정기간행물)] - Cauley JA / 2001 / Timing of estrogen replacement therapy for optimal osteoporosis prevention / J Clin Endocrinol Metab 86 : 5700 ~ 5705
2. [학술지(정기간행물)] - Aitken JM / 1972 / Osteoporosis after oophorectomy in the mature female rat and the effect of oestrogen and-or progestogen replacement therapy in its prevention / J Endocrinol 55 : 79 ~ 87
3. [학술지(정기간행물)] - Albertazzi / 1999 / Dietary soy supplementation and phytoestrogen levels / Obstetrics Gynecol 94 : 229 ~ 231
4. [학술지(정기간행물)] - Aviram M / 2000 / Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL and platelet aggregation: studies in humans and in atherosclerotic apolipoprotein E-deficient mice / Am J Clin Natr 71 : 1062 ~ 1076
5. [학술지(정기간행물)] - Cauley JA / 2001 / Timing of estrogen replacement therapy for optimal osteoporosis prevention / J Clin Endocrinol Metab 86 : 5700 ~ 5705
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UCI(KEPA) : I410-ECN-0101-2009-510-018855903