Ameliorative Effects of Pomegranate Peel Extract against Dietary-Induced Nonalcoholic Fatty Liver in Rats

Siham N. K. Al-Shaaibi; Mostafa I. Waly; Lyutha Al-Subhi; Mohamed H. Tageldin; Nada M. Al-Balushi; Mohammad S. Rahman

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저자정보: Siham N. K. Al-Shaaibi (Sultan Qaboos University) Mostafa I. Waly (Sultan Qaboos University) Lyutha Al-Subhi (Sultan Qaboos University) Mohamed H. Tageldin (Sultan Qaboos University) Nada M. Al-Balushi (Sultan Qaboos University) Mohammad S. Rahman (Sultan Qaboos University)

저널정보: 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.21 No.1

발행연도: 2016.3

수록면: 14 - 23 (10page)

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Non-alcoholic fatty liver disease (NAFLD) is caused by fat accumulation and is associated with oxidative stress. In this study, we investigated the potential protective effect of pomegranate (Punica granatum L.) peel extract (PPE) against oxidative stress in the liver of rats with NAFLD. Sprague-Dawley rats were fed a high fat diet (HFD), 20% corn oil, or palm oil for 8 weeks in the presence or absence of PPE. The control group was fed a basal diet. The progression of NAFLD was evaluated histologically and by measuring liver enzymes (alanine transaminase and aspartate transaminase), serum lipids (triglycerides and total cholesterol), and oxidative stress markers. The HFD feeding increased the body weight and caused NAFLD, liver steatosis, hyperlipidemia, oxidative stress, and elevated liver enzymes. Administration of PPE ameliorated the hepatic morphology, reduced body weight, improved liver enzymes, and inhibited lipogenesis. Furthermore, PPE enhanced the cellular redox status in the liver tissue of rats with NAFLD. Our findings suggest that PPE could improve HFD-induced NAFLD via abolishment of hepatic oxidative damage and hyperlipidemia. PPE might be considered as a potential lead material in the treatment of NAFLD and obesity through the modulation of lipid metabolism.

#pomegranate peel extract #nonalcoholic fatty liver disease #oxidative stress

참고문헌 (45)

참고문헌 신청

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