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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 172 - 177 (6page)
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Upregulation of pro-inflammatory mediators contributes to-cell destruction and enhanced infiltration of immune cells intopancreatic islets during development of type 1 diabetesmellitus. In this study, we examined the regulatory effects andthe mechanisms of action of celastrol against cytotoxicity andpro-inflammatory immune responses in the RINm5F rat pancreatic-cell line stimulated with a combination of interleukin-1beta, tumor necrosis factor-alpha, and interferon-. Celastrolsignificantly restored cytokine-induced cell death and significantlyinhibited cytokine-induced nitric oxide production. Inaddition, the protective effect of celastrol was correlated with areduction in pro-inflammatory mediators, such as inducible nitricoxide synthase, cyclooxygenase-2, and CC chemokine ligand2. Furthermore, celastrol significantly suppressed cytokine-induced signaling cascades leading to nuclear factor kappaB (NF-B) activation, including IB-kinase (IKK) activation,IB degradation, p65 phosphorylation, and p65 DNA bindingactivity. These results suggest that celastrol may exert its cytoprotectiveactivity by suppressing cytokine-induced expressionof pro-inflammatory mediators by inhibiting activation ofNF-B in RINm5F cells.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Allison AC / 2001 / Celastrol, a potent antioxidant and anti-inflammatory drug, as a possible treatment for Alzheimer's disease / Prog Neuropsychopharmacol Biol Psychiatry 25
Cameron MJ / 2000 / Differential expression of CC chemokines and the CCR5 receptor in the pancreas is associated with progression to type I diabetes / J Immunol 165 : 1102 ~
Cardozo AK / 2001 / A comprehensive analysis of cytokine-induced and nuclear factor-kappa B-dependent genes in primary rat pancreatic beta-cells / J Biol Chem 276 : 48879 ~
Chen MC / 2001 / Monocyte chemoattractant protein-1 is expressed in pancreatic islets from prediabetic NOD mice and in interleukin-1 beta-exposed human and rat islet cells /
Corbett JA / 1992 / Does nitric oxide mediate autoimmune destruction of beta-cells? Possible therapeutic interventions in IDDM / Diabetes 41 : 897 ~ 903
Cameron MJ / 2000 / Differential expression of CC chemokines and the CCR5 receptor in the pancreas is associated with progression to type I diabetes / J Immunol 165 : 1102 ~
Cardozo AK / 2001 / A comprehensive analysis of cytokine-induced and nuclear factor-kappa B-dependent genes in primary rat pancreatic beta-cells / J Biol Chem 276 : 48879 ~
Chen MC / 2001 / Monocyte chemoattractant protein-1 is expressed in pancreatic islets from prediabetic NOD mice and in interleukin-1 beta-exposed human and rat islet cells /
Corbett JA / 1992 / Does nitric oxide mediate autoimmune destruction of beta-cells? Possible therapeutic interventions in IDDM / Diabetes 41 : 897 ~ 903
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