지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 676 - 686 (11page)
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Purpose We examined clinical and dosimetric factors as predictors of symptomatic radiation pneumonitis(RP) in lung cancer patients and evaluated the relationship between interstitial lungchanges in the pre-radiotherapy (RT) computed tomography (CT) and symptomatic RP.
Materials and MethodsMedical records and dose volume histogram data of 60 lung cancer patients from August2005 to July 2006 were analyzed. All patients were treated with three dimensional (3D)conformal RT of median 56.9 Gy. We assessed the association of symptomatic RP with clinicaland dosimetric factors.
ResultsWith a median follow-up of 15.5 months (range, 6.1 to 40.9 months), Radiation TherapyOncology Group grade ! 2 RP was observed in 14 patients (23.3%). Five patients (8.3%)died from RP. The interstitial changes in the pre-RT chest CT, mean lung dose (MLD), andV30 significantly predicted RP in multivariable analysis (p=0.009, p < 0.001, and p < 0.001,respectively). MLD, V20, V30, and normal tissue complication probability normal tissue complicationprobability (NTCP) were associated with the RP grade but less so for grade 5 RP.
The risk of RP grade ! 2, ! 3, or ! 4 was higher in the patients with interstitial lung change(grade 2, 15.6% to 46.7%, p=0.03; grade 3, 4.4% to 40%, p=0.002; grade 4, 4.4% to 33.3%,p=0.008). Four of the grade 5 RP patients had diffuse interstitial change in pre-RT CT andreceived chemoradiotherapy.
ConclusionOur study identified diffuse interstitial disease as a significant clinical risk for RP, particularlyfatal RP. We showed the usefulness of MLD, V20, V30, and NTCP in predicting the incidenceand severity of RP.
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참고문헌 (23)
참고문헌 신청
Graves PR / 2010 / Radiation pulmonary toxicity : from mechanisms to management / Semin Radiat Oncol 20:201~207
Yamashita H / 2010 / Prescreening based on the presence of CT-scan abnormalities and biomarkers(KL-6 and SP-D)may reduce severe radiation pneumonitis after stereotactic radiotherapy / Radiat Oncol 5:32
[학술지(정기간행물
Baker R / 2013 / Clinical and dosimetric predictors of radiation pneumonitis in a large series of patients treated with stereotactic body radiation therapy to the lung / Int
Choy H / 1998 / Multiinstitutional phase II trial of paclitaxel, carboplatin, and concurrent radiation therapy for locally advanced non-small-cell lung cancer / J Clin Oncol
Yamashita H / 2010 / Prescreening based on the presence of CT-scan abnormalities and biomarkers(KL-6 and SP-D)may reduce severe radiation pneumonitis after stereotactic radiotherapy / Radiat Oncol 5:32
[학술지(정기간행물
Baker R / 2013 / Clinical and dosimetric predictors of radiation pneumonitis in a large series of patients treated with stereotactic body radiation therapy to the lung / Int
Choy H / 1998 / Multiinstitutional phase II trial of paclitaxel, carboplatin, and concurrent radiation therapy for locally advanced non-small-cell lung cancer / J Clin Oncol
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