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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 26 - 33 (8page)
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초록· 키워드
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Purpose Tumor response to neoadjuvant chemotherapy (NAC) may adversely affect the identificationand accuracy rate of sentinel lymph node biopsy (SLNB). This study was conducted toevaluate the feasibility of SLNB in node-positive breast cancer patients with negative axillaryconversion after NAC.
Materials and MethodsNinety-six patients with positive nodes at presentation were prospectively enrolled.
18Fluorodeoxyglucose-positron emission tomography (18F-FDG PET) and ultrasonographywere performed before and after NAC. A metastatic axillary lymph node was defined aspositive if it was positive upon both 18F-FDG PET and ultrasonography, while it was considerednegative if it was negative upon both 18F-FDG PET and ultrasonography.
ResultsAfter NAC, 55 cases (57.3%) became clinically node-negative, while 41 cases (42.7%)remained node-positive. In the entire cohort, the sentinel lymph node (SLN) identificationand false-negative rates were 84.3% (81/96) and 18.4% (9/49), respectively. In thenegative axillary conversion group, the results of SLNB showed an 85.7% (48/55) identificationrate and 16.7% (4/24) false-negative rate.
ConclusionFor breast cancer patients with clinically positive nodes at presentation, it is difficult toconclude whether the SLN accurately represents the metastatic status of all axillary lymphnodes, even after clinically negative node conversion following NAC.
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참고문헌 (21)
참고문헌 신청
Ahn JH / 2010 / The role of ultrasonography and FDG-PET in axillary lymph node staging of breast cancer / Acta Radiol 51 : 859 ~ 865
Boughey JC / 2013 / Sentinel lymph node surgery after neoadjuvant chemotherapy in patients with node-positive breast cancer : the ACOSOG Z1071(Alliance)clinical trial / JAMA
Buchholz TA / 2008 / Statement of the science concerning locoregional treatments after preoperative chemotherapy for breast cancer : a National Cancer Institute conference /
Drew PJ / 2001 / Evaluation of response to neoadjuvant chemoradiotherapy for locally advanced breast cancer with dynamic contrast-enhanced MRI of the breast / Eur J Surg Onc
Fisher B / 1998 / Effect of preoperative chemotherapy on the outcome of women with operable breast cancer / J Clin Oncol 16 : 2672 ~ 2685
Boughey JC / 2013 / Sentinel lymph node surgery after neoadjuvant chemotherapy in patients with node-positive breast cancer : the ACOSOG Z1071(Alliance)clinical trial / JAMA
Buchholz TA / 2008 / Statement of the science concerning locoregional treatments after preoperative chemotherapy for breast cancer : a National Cancer Institute conference /
Drew PJ / 2001 / Evaluation of response to neoadjuvant chemoradiotherapy for locally advanced breast cancer with dynamic contrast-enhanced MRI of the breast / Eur J Surg Onc
Fisher B / 1998 / Effect of preoperative chemotherapy on the outcome of women with operable breast cancer / J Clin Oncol 16 : 2672 ~ 2685
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