메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류
인문학
인문학 일반 역사학 철학 종교학 어문학 기타 인문학
사회과학
사회과학 일반 경영학 관광학 교육학 군사학 문헌정보학 법학 사회학 신문방송학 심리과학 정치외교학 지리학 행정학 경제학 무역학 인류학 기타 사회과학
자연과학
자연과학 일반 물리학 생물학 생활과학 수학·통계학 천문학 지구과학 화학 기타 자연과학
공학
공학 일반 건축공학 기계공학 산업공학 재료·에너지공학 전기전자공학 조선해양공학 화학공학 컴퓨터학 기타공학
의약학
의학 일반 간호학 수의학 약학 한의학 기초의학 임상의학 기타 의약학
농수해양학
농수해양학 일반 농학 수산학 식품과학 임학 축산학 해상운송학 기타 농수해양학
예술체육학
예술 일반 디자인 미술 미용 사진 음악학 의상 체육 공연매체예술 기타 예술체육학
복합학
학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

ENG

추천
검색

논문 기본 정보

자료유형
학술저널
저자정보
이한용 (대구파티마병원 외과) 박호용 (경북대학교 의과대학 외과학교실) 강진구 (대구파티마병원 외과)
저널정보
한국유방암학회 Journal of Breast Disease Journal of Breast Disease 제4권 제2호
발행연도
2016.12
수록면
42 - 47 (6page)
DOI
https://doi.org/10.14449/jbd.2016.4.2.42

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색

초록· 키워드

오류제보하기
Purpose: Sentinel lymph node biopsy (SLNB) has been a reliable technique in breast cancer staging. However, some authors reported that SLNB after neoadjuvant chemotherapy (NAC) could lead to low identification rates and high false-negative rates. Hence, whether only SLNB can be applied after NAC is controversial. The aim of this study was to identify predictive factors of residual metastatic axillary lymph nodes after NAC. Methods: In this study, 71 breast cancer patients with clinically positive lymph nodes (cN1), who received axillary lymph node dissection (ALND) after NAC between July 2012 and September 2014, were enrolled. The patients were divided into N1 and N0 groups according to the presence of residual axillary metastatic lymph nodes after ALND. We compared the clinical, radiological, and immunohistological factors between two groups. Results: In the 71 patients with cN1who received NAC, N1 and N0 status were confirmed after surgery in 43 and 28 patients, respectively. The clinical stage at diagnosis was IIA in one patient, IIB in 15 patients, IIIA in 35 patients, IIIB in two patients, IIIC in 10 patients, and IV in eight patients. Most of the patients (n=57) received eight cycles (four cycles of anthracycline and four of taxane) of chemotherapy. Our study showed that the primary tumor was downstaged in 58 of the 71 patients (81.7%). Sixteen patients (22.5%) had pathological complete response (pCR) and 42 (59.2%) had pathological partial response. In a multivariate analysis, tumor response and human epidermal growth factor receptor 2 (HER2) were identified as significant factors. However, no significant differences were observed in the results of postchemotherapy ultrasonography, and pre- or post-positron emission tomography computed tomography (maximum standardized uptake value reduction). Conclusion: In the NAC setting, SLNB before ALND is feasible for tumors predicted to have a pCR or if target therapy had been administered for HER2-positive breast cancer.
#Breast neoplasms #Neoadjuvant chemotherapy #Sentinel lymph node biopsy

목차

등록된 정보가 없습니다.

참고문헌 (18)

참고문헌 신청
Kuehn T / 2013 / Sentinel-lymph-node biopsy in patients with breast cancer before and after neoadjuvant chemotherapy (SENTINA): a prospective, multicentre cohort study / Lancet Oncol 14:609~618 google schola Boughey JC / 2013 / Sentinel lymph node surgery after neoadjuvant chemotherapy in patients with node-positive breast cancer: the ACOSOG Z1071 (Alliance) clinical trial / JAMA 310:1455~1461 google schola 한아람 / 2013 / Reliability of Sentinel Lymph Node Biopsy after Neoadjuvant Chemotherapy in Breast Cancer Patients / Journal of Breast Cancer 16(4):378~385 dbpia Nason KS / 2000 / Increased false negative sentinel node biopsy rates after preoperative chemotherapy for invasive breast carcinoma / Cancer 89:2187~2194 google schola Wolmark N / 2001 / Preoperative chemotherapy in patients with operable breast cancer: nine-year results from National Surgical Adjuvant Breast and Bowel Project B-18 / J Natl Cancer Inst Monogr (30):96~102 google schola

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

최근 본 자료

전체보기

댓글(0)

0