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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제16권 제3호
- 발행연도
- 2018.1
- 수록면
- 310 - 315 (6page)
이용수
초록· 키워드
오류제보하기
Objective: Bipolar disorder (BD) is associated with increased rates of cardiovascular diseases. There is growing evidence that blood viscosity may have a common role, correlated with well-known major risk factors that promote cardiovascular disease. In this study we aimed to investigate the whole blood viscosity (WBV) in different stages of BD. Methods: A total of 121 bipolar patients and 41 age-gender matched healthy controls were included. Forty-four of bipolar patients were in manic, 35 were depressed and 42 were in euthymic state. WBV was calculated from hematocrit and total plasma protein according to Simone’s formula at low and high shear rates (LSR and HSR). Results: WBV at HSR of manic group was 16.91±1.01, depressive group was 17.23±0.80, euthymic group was 17.63± 0.95, and control group was 17.52±0.71 (p =0.001). WBV at LSR of manic depressive, euthymic and control group were 53.10±20.58, 60.30±17.02, 68.91±20.33, and 62.01±19.28, respectively (p =0.001). Both WBV at HSR and LSR of manic group was significantly lower than that of the euthymic and control groups (p =0.001 and 0.010 respectively for HSR, p =0.001 and 0.011 respectively for LSR). WBV was significantly positively correlated with lipid profile except high density lipoprotein (HDL). Conclusion: Our results demonstrate a decrement in blood viscosity in manic episode compared with euthymics and controls. Positive correlation of blood viscosity with lipid parameters (except HDL), and negative correlation with number of previous manic episodes suggest that manic episode has favorable effect on cardiovascular risk regarding to blood viscosity.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Sylvia LG / 2015 / Medical burden in bipolar disorder: findings from the Clinical and Health Outcomes Initiative in Comparative Effectiveness for Bipolar Disorder study (Bipolar CHOICE) / Bipolar Disord 17:212~223
Peters SA / 2017 / Plasma and blood viscosity in the prediction of cardiovascular disease and mortality in the Scottish Heart Health Extended Cohort Study / Eur J Prev Cardiol 24:161~167
Kensey KR / 2003 / The mechanistic relationships between hemorheological characteristics and cardiovascular disease / Curr Med Res Opin 19:587~596
Cowan AQ / 2012 / Importance of blood rheology in the pathophysiology of atherothrombosis / Cardiovasc Drugs Ther 26:339~348
Allen MT / 1995 / Hemoconcentration and stress: a review of physiological mechanisms and relevance for cardiovascular disease risk / Biol Psychol 41:1~27
Peters SA / 2017 / Plasma and blood viscosity in the prediction of cardiovascular disease and mortality in the Scottish Heart Health Extended Cohort Study / Eur J Prev Cardiol 24:161~167
Kensey KR / 2003 / The mechanistic relationships between hemorheological characteristics and cardiovascular disease / Curr Med Res Opin 19:587~596
Cowan AQ / 2012 / Importance of blood rheology in the pathophysiology of atherothrombosis / Cardiovasc Drugs Ther 26:339~348
Allen MT / 1995 / Hemoconcentration and stress: a review of physiological mechanisms and relevance for cardiovascular disease risk / Biol Psychol 41:1~27
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