지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 514 - 519 (6page)
이용수
초록· 키워드
오류제보하기
ObjectiveaaBipolar disorder (BD) is a chronic mood disorder characterized by recurrent episodes that has a lifetime prevalence of 0.4– 5.5%. The neurochemical mechanism of BD is not fully understood. Oxidative stress in neurons causes lipid peroxidation in proteins associated with neuronal membranes and intracellular enzymes and it may lead to dysfunction in neurotransmitter reuptake and enzyme activities. These pathological processes are thought to occur in brain regions associated with affective functions and emotions in BD. The relationship between the number of manic episodes and total oxidant-antioxidant capacity was investigated in this study. MethodsaaEighty-two BD patients hospitalized due to manic symptoms and with no episodes of depression were enrolled in the study. Thirty of the 82 patients had had their first episode of mania, and the other 52 patients had had two or more manic episodes. The control group included 45 socio-demographically matched healthy individuals. Serum total antioxidant capacity (TAC) and total oxidant capacity (TOC) measurements of the participants were performed. The oxidative stress index (OSI) was calculated by TOC/TAC. ResultsaaThere were no significant differences in OSI scores between BD patients with first-episode mania and BD patients with more than one manic episode. However, OSI scores in both groups were significantly higher than in the control group. TOC levels of BD patients with first-episode mania were found to be significantly higher than TOC levels of BD patients with more than one manic episode and healthy controls. There were no significant differences in TAC levels between BD patients with first-episode mania and BD patients with more than one manic episode. TAC levels in both groups were significantly higher than in the control group. ConclusionaaSignificant changes in oxidative stress indicators were observed in this study, confirming previous studies. Increased levels of oxidants were shown with increased disease severity rather than with the number of manic episodes. Systematic studies, including of each period of the disorder, are needed for using the findings indicating deterioration of oxidative parameters.
목차
등록된 정보가 없습니다.
참고문헌 (42)
참고문헌 신청
Morgan VA / 2005 / The epidemiology of bipolar disorder: sociodemographic, disability and service utilization data from the Australian National Study of Low Prevalence (Psychotic) Disorders / Bipolar Disord 7:326~337
Sun X / 2006 / Downregulation in components of the mitochondrial electron transport chain in the postmortem frontal cortex of subjects with bipolar disorder / J Psychiatry Neurosci 31:189~196
MacDonald ML / 2006 / Decrease in creatine kinase messenger RNA expression in the hippocampus and dorsolateral prefrontal cortex in bipolar disorder / Bipolar Disord 8:255~264
Iwamoto K / 2005 / Altered expression of mitochondria-related genes in postmortem brains of patients with bipolar disorder or schizophrenia, as revealed by large-scale DNA microarray analysis / Hum Mol Genet 14:241~253
Konradi C / 2004 / Molecular evidence for mitochondrial dysfunction in bipolar disorder / Arch Gen Psychiatry 61:300~308
Sun X / 2006 / Downregulation in components of the mitochondrial electron transport chain in the postmortem frontal cortex of subjects with bipolar disorder / J Psychiatry Neurosci 31:189~196
MacDonald ML / 2006 / Decrease in creatine kinase messenger RNA expression in the hippocampus and dorsolateral prefrontal cortex in bipolar disorder / Bipolar Disord 8:255~264
Iwamoto K / 2005 / Altered expression of mitochondria-related genes in postmortem brains of patients with bipolar disorder or schizophrenia, as revealed by large-scale DNA microarray analysis / Hum Mol Genet 14:241~253
Konradi C / 2004 / Molecular evidence for mitochondrial dysfunction in bipolar disorder / Arch Gen Psychiatry 61:300~308
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Clinical Characteristics of Pediatric Bipolar Disorder by Subtype in a Korean Inpatient Sample
소아청소년정신의학
2015 .12
-
Polydipsia as a Precursor of Manic Episode in Bipolar Affective Disorder Patients with Alcohol Use Disorder
Clinical Psychopharmacology and Neuroscience
2018 .01
-
후기 발생 조증 환자의 정신병리와 임상적 특징 : 후향적 의무기록 조사 연구
생물치료정신의학
2015 .02
-
Significant Shortening of Leukocyte Telomere Length in Korean Patients with Bipolar Disorder 1
Clinical Psychopharmacology and Neuroscience
2021 .08
-
Using the Young Mania Rating Scale for Identifying Manic Symptoms in Patients with Schizophrenia
Yonsei Medical Journal
2016 .01
-
Depression and Mania Induce Pro-inflammatory Activation of Macrophages Following Application of Serum from Individuals with Bipolar Disorder
Clinical Psychopharmacology and Neuroscience
2018 .01
-
Epidemiologic and Etiological Features of Korean Patients With Behcet’s Disease
대한류마티스학회지
2021 .10
-
Cortical Thickness and Surface Area Abnormalities in Bipolar I and II Disorders
PSYCHIATRY INVESTIGATION
2021 .09
-
Does Blood Flow Change according to Mood? Blood Rheology in Bipolar Disorder
Clinical Psychopharmacology and Neuroscience
2018 .01
-
Neuromolecular Etiology of Bipolar Disorder: Possible Therapeutic Targets of Mood Stabilizers
Clinical Psychopharmacology and Neuroscience
2022 .05
-
유럽인 자료로 산출된 양극성 장애 다유전자 위험 점수의 한국인 양극성 장애 환자에의 적용
신경정신의학
2021 .08
-
Carpal Tunnel Syndrome in Behçet’s Disease
Yonsei Medical Journal
2015 .01
-
Are Mannan-binding Lectine Serin Protease-2 and Alpha-1-microglobulin and Bukinin Precursor the Potential Biomarkers of Manic Episode? A Study via Urinary Proetomic Analysis
Clinical Psychopharmacology and Neuroscience
2021 .01
-
Is There a Correlation Between Behçet Disease and Lower Urinary Tract Symptoms?
International Neurourology Journal
2020 .01
-
Genetic Association of the PERIOD3 (Per3) Clock Gene with Bipolar Disorder
PSYCHIATRY INVESTIGATION
2017 .01
-
Higher Prevalence of Metabolic Syndrome in Child-adolescent Patients with Bipolar Disorder
Clinical Psychopharmacology and Neuroscience
2020 .01
-
Similarities of Aspects of Biological Rhythms between Major Depression and Bipolar II Disorder Compared to Bipolar I Disorder: A Finding from the Early-Onset Mood Disorder Cohort
PSYCHIATRY INVESTIGATION
2019 .01
-
Detecting Manic State of Bipolar Disorder Based on Support Vector Machine and Gaussian Mixture Model Using Spontaneous Speech
PSYCHIATRY INVESTIGATION
2018 .01
-
Measurement of Contrast Sensitivity in Patients with Behçet’s Disease without Ocular Involvement
Korean Journal of Ophthalmology
2019 .01
-
Comparison of Serum Uric Acid in Major Depressive Disorder and Bipolar Disorder: a Retrospective Chart Review Study
Journal of Korean Medical Science
2020 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0