종양과 구강각질세포주에서 Celecoxib과 Indomethacin의 Cyclooxygenase-2 비의존적 기전에 의한 억제 효과

성명훈; 김광현; 김동영; 박찬일; 노종렬; 하정훈

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자료유형: 학술저널

저자정보: 성명훈 김광현 김동영 박찬일 노종렬 하정훈

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제47권 제6호

발행연도: 2004.1

수록면: 562 - 568 (7page)

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Background and Objectives：Overexpression of cyclooxygenase-2 (COX-2), a rate-limiting enzyme in the generation of pro-stanoids from arachidonic acid, has known to be closely related to tumorigenesis, tumor growth, angiogenesis, and metastasis. Selective or non-selective COX-2 inhibitors have been used for the growth inhibition of cancers with preventative intents；how-ever, it has been sugested recently that cancer cels have COX-2-independent mechanisms. Materials and Method：Using MT assat and cel counts, we observed the growth inhibition of SC VI, CT-26 and B16F10 murine cancer cel lines when treated COX-2 expression of these cel lines was analyzed by western bloting and compared with the degree of inhibition by the drugs. Results：The growth inhibition of the cell lines by the drugs was clearly demonstrated in a concentration-dependent maner and depended on the type of cell lines and test drug. The in vitro viability asay revealed that CT-26 expresing COX-2 protein was slightly inhibited but SC VI and B16F10 without COX-2 expression were moderate-to-highly inhibited by the drug treatment. n. HOK 16B showed a resistance by concentrations les than 25 μM of celecoxib, which implies that celecoxib has a more selective effect on tumor cells and is safer than indomethacin. Conclusion：The growth of cancer cels was inhibited by celecoxib and indomethacin treatment, which depends on the type of cancer, treated drug, and its concentration. Their suppresive efect is not closely related to the COX-2 expression of cancer cells.

#세포주·종양·생쥐·억제제. #· Cancer· Mouse· Cyclooxygenase-2· Inhibitors.

참고문헌 (13)

참고문헌 신청

/ 1887 / Cyclooxygenase-2 expression inhuman colon cancer cells increases metastatic potential 94 : 3336 ~ 3340

/ 1995 / Alterations in cellular adhesion and apoptosisin epithelial cells overexpressing prostaglandin endoperoxide synthase2 83 : 493 ~ 501

/ 1997 / Expressionof cyclooxygenase-2 in human gastric carcinoma 57 : 1276 ~ 1280

/ 1999 / Cyclooxygenase-2 expression is up-regulated in squamous cell carcinomaof the head and neck 59 : 991 ~ 994

/ 2000 / Celecoxib prevents tumor growth in vivo without toxicity to normalgut:Lack of correlation between in vitro and in vivo models 60 : 6045 ~ 6051

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