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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한자기공명의과학회 Investigative Magnetic Resonance Imaging Investigative Magnetic Resonance Imaging 제21권 제4호
- 발행연도
- 2017.1
- 수록면
- 199 - 209 (11page)
이용수
초록· 키워드
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Purpose: Caffeine is the most widely consumed psychostimulant. It is often adopted as a tool to modulate brain activations in fMRI studies. However, its pharmaceutical effect on task-induced deactivation has not been fully examined in fMRI. Therefore, the purpose of this study was to examine the effect of caffeine on both activation and deactivation under sustained attention.
Materials and Methods: Task fMRI was acquired from 26 caffeine naive healthy volunteers before and after taking caffeine pill (200 mg).
Results: Statistical analysis showed an increase in cognition-load dependent task activation but a decrease in load dependent de-activation after caffeine ingestion.
Increase of attention and memory task activation and its load-dependence suggest a beneficial effect of caffeine on the brain even though it has no overt behavior improvement. The reduction of deactivation by caffeine and its load-dependence indicate reduced facilitation from task-negative networks.
Conclusion: Caffeine affects brain activity in a load-dependent manner accompanied by a disassociation between task-positive network and task-negative network.
목차
등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Adan A / 2008 / Early effects of caffeinated and decaffeinated coffee on subjective state and gender differences / Prog Neuropsychopharmacol Biol Psychiatry 32 : 1698 ~ 1703
Addicott MA / 2009 / The effect of daily caffeine use on cerebral blood flow: how much caffeine can we tolerate? / Hum Brain Mapp 30 : 3102 ~ 3114
Axelrod J / 1953 / The fate of caffeine in man and a method for its estimation in biological material / J Pharmacol Exp Ther 107 : 519 ~ 523
Bendlin BB / 2007 / Caffeine attenuates practice effects in word stem completion as measured by fMRI BOLD signal / Hum Brain Mapp 28 : 654 ~ 662
Binder JR / 2012 / Task-induced deactivation and the"resting"state / Neuroimage 62 : 1086 ~ 1091
Addicott MA / 2009 / The effect of daily caffeine use on cerebral blood flow: how much caffeine can we tolerate? / Hum Brain Mapp 30 : 3102 ~ 3114
Axelrod J / 1953 / The fate of caffeine in man and a method for its estimation in biological material / J Pharmacol Exp Ther 107 : 519 ~ 523
Bendlin BB / 2007 / Caffeine attenuates practice effects in word stem completion as measured by fMRI BOLD signal / Hum Brain Mapp 28 : 654 ~ 662
Binder JR / 2012 / Task-induced deactivation and the"resting"state / Neuroimage 62 : 1086 ~ 1091
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