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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 146 - 151 (6page)
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Background/Aims: A low vitamin D level has been associated with metabolic syndrome and diabetes. However, an association between a low vitamin D level and nonalcoholic fatty liver disease (NAFLD) has not yet been definitively established. This study aimed to characterize the relationship between a vitamin D level and NAFLD in Korea.
Methods: A cross-sectional study involving 6,055 health check-up subjects was conducted. NAFLD was diagnosed on the basis of typical ultrasonographic findings and a history of alcohol consumption.
Results: The subjects were aged 51.7±10.3 years (mean±SD) and 54.7% were female. NAFLD showed a significant inverse correlation with the vitamin D level after adjusting for age and sex [odds ratio (OR)=0.85, 95% confidence interval (CI)=0.75–0.96]. The age- and sex-adjusted prevalence of NAFLD decreased steadily with increasing vitamin D level [OR=0.74, 95% CI=0.60–0.90, lowest quintile (≤14.4 ng/mL) vs highest quintile (≥28.9 ng/mL), p for trend <0.001]. Multivariate regression analysis after adjusting for other metabolic factors revealed that NAFLD showed a significant inverse correlation with both the vitamin D level (>20 ng/mL) [OR=0.86, 95% CI=0.75-0.99] and the quintiles of the vitamin D level in a dose-dependent manner (p for trend=0.001).
Conclusions: The serum level of vitamin D, even when within the normal range, was found to be inversely correlated with NAFLD in a dose-dependent manner. Vitamin D was found to be inversely correlated with NAFLD independent of known metabolic risk factors. These findings suggest that vitamin D exerts protective effects against NAFLD.
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참고문헌 (24)
참고문헌 신청
Vernon G / 2011 / Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults / Aliment Pharmacol Ther 34:274~285
Almeda-Valdés P / 2009 / Metabolic syndrome and non-alcoholic fatty liver disease / Ann Hepatol 8(Suppl 1):S18~S24
Khashab MA / 2008 / Nonalcoholic fatty liver disease as a component of the metabolic syndrome / Curr Gastroenterol Rep 10:73~80
Kim D / 2012 / Nonalcoholic fatty liver disease is associated with coronary artery calcification / Hepatology 56:605~613
Chen SH / 2011 / Relationship between nonalcoholic fatty liver disease and metabolic syndrome / J Dig Dis 12:125~130
Almeda-Valdés P / 2009 / Metabolic syndrome and non-alcoholic fatty liver disease / Ann Hepatol 8(Suppl 1):S18~S24
Khashab MA / 2008 / Nonalcoholic fatty liver disease as a component of the metabolic syndrome / Curr Gastroenterol Rep 10:73~80
Kim D / 2012 / Nonalcoholic fatty liver disease is associated with coronary artery calcification / Hepatology 56:605~613
Chen SH / 2011 / Relationship between nonalcoholic fatty liver disease and metabolic syndrome / J Dig Dis 12:125~130
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