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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 379 - 386 (8page)
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Background/Aims: Vitamin E improves the biochemical profiles and liver histology in nonalcoholic steatohepatitis, but the role of vitamin E is not clearly defined in the management of nonalcoholic fatty liver disease (NAFLD) which includes both simple steatosis and steatohepatitis. Co-morbid metabolic syndrome increases the probability of steatohepatitis in NAFLD. In this study, we aimed to determine the short-term effects of vitamin E and off-treatment durability of response in a propensity-score matched cohort of NAFLD patients with metabolic syndrome.
Methods: A retrospective cohort was constructed by retrieving 526 consecutive NAFLD patients from the electronic medical record data warehouse of a tertiary referral hospital in South Korea. Among them, 335 patients (63.7%) had metabolic syndrome and were eligible for vitamin E therapy. In order to assess the effect of vitamin E, propensity score matching was used by matching covariates between control patients (n=250) and patients who received vitamin E (n=85).
Results: The PS-matched vitamin E group (n=58) and control group (n=58) exhibited similar baseline metabolic profiles. After 6 months of vitamin E therapy, the mean ALT levels decreased significantly compared to PS-matched control (P<0.01). The changes in metabolic profiles (body weight, lipid and glucose levels) did not differ between control and vitamin E groups during the study period.
Conclusions: Short-term vitamin E treatment significantly reduces ALT levels in NAFLD patients with metabolic syndrome, but metabolic profiles are not affected by vitamin E.
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참고문헌 (23)
참고문헌 신청
Adams LA / 2005 / The natural history of nonalcoholic fatty liver disease : a population-based cohort study / Gastroenterology 129 : 113 ~ 121
Browning JD / 2004 / Molecular mediators of hepatic steatosis and liver injury / J Clin Invest 114 : 147 ~ 152
Chalasani N / 2012 / The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, Americ
Chalasani N / 2012 / The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Gastroenterological Association, American Associat
Chang CY / 2006 / Therapy of NAFLD:antioxidants and cytoprotective agents / J Clin Gastroenterol 40 (1) : S51 ~ S60
Browning JD / 2004 / Molecular mediators of hepatic steatosis and liver injury / J Clin Invest 114 : 147 ~ 152
Chalasani N / 2012 / The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, Americ
Chalasani N / 2012 / The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Gastroenterological Association, American Associat
Chang CY / 2006 / Therapy of NAFLD:antioxidants and cytoprotective agents / J Clin Gastroenterol 40 (1) : S51 ~ S60
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