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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 1,083 - 1,091 (9page)
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Gut microbiota play critical physiological roles in energy extraction from the intestine and in the control of systemic immunity, as well as local intestinal immunity. Disturbance of gut microbiota leads to the development of several diseases, such as colitis, inflammatorybowel diseases, metabolic disorders, cancer, etc. From a metabolic point of view, the gut is a large metabolic organ and one of the first to come into contact with dietary fats. Interestingly, excessive dietary fat has been incriminated as a primary culpritof metabolic syndrome and obesity. After intake of high-fat diet or Western diet, extensive changes in gut microbiota have been observed, which may be an underlying cause of alterations in whole body metabolism and nutrient homeostasis. Here, we summarizerecent data on changes in the gut microbiota and immunity associated with dietary fat, as well as their relationships with the pathogenesis of metabolic syndrome. These findings may provide insight into the understanding of the complex pathophysiologyrelated to the development of metabolic diseases and offer an opportunity to develop novel candidates for therapeutic agents.
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참고문헌 (25)
참고문헌 신청
Alenghat T / 2013 / Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis / Nature 504 : 153 ~ 157
Arpaia N / 2013 / Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation / Nature 504 : 451 ~ 455
Backhed F / 2004 / The gut microbiota as an environmental factor that regulates fat storage / Proc Natl Acad Sci U S A 101 : 15718 ~ 15723
Backhed F / 2007 / Mechanisms underlying the resistance to diet-induced obesity in germfree mice / Proc Natl Acad Sci U S A 104 : 979 ~ 984
Beltran-Sanchez H / 2013 / Prevalence and trends of metabolic syndrome in the adult U.S. population, 1999-2010 / J Am Coll Cardiol 62 : 697 ~ 703
Arpaia N / 2013 / Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation / Nature 504 : 451 ~ 455
Backhed F / 2004 / The gut microbiota as an environmental factor that regulates fat storage / Proc Natl Acad Sci U S A 101 : 15718 ~ 15723
Backhed F / 2007 / Mechanisms underlying the resistance to diet-induced obesity in germfree mice / Proc Natl Acad Sci U S A 104 : 979 ~ 984
Beltran-Sanchez H / 2013 / Prevalence and trends of metabolic syndrome in the adult U.S. population, 1999-2010 / J Am Coll Cardiol 62 : 697 ~ 703
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