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논문 기본 정보

자료유형
학술저널
저자정보
Donghun Oh (Yonsei University College of Medicine) Keun-Ah Cheon (Yonsei University College of Medicine)
저널정보
대한소아청소년정신의학회 소아청소년정신의학 소아청소년정신의학 제31권 제3호
발행연도
2020.7
수록면
131 - 145 (15page)

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초록· 키워드

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The microbiota-gut-brain axis, which refers to the bidirectional communication pathway between gut bacteria and the central nervous system, has a profound effect on important brain processes, from the synthesis of neurotransmitters to the modulation of complex behaviors such as sociability and anxiety. Previous studies have revealed that the gut microbiota is potentially related to not only gastrointestinal disturbances, but also social impairment and repetitive behavior—core symptoms of autism spectrum disorder (ASD). Although studies have been conducted to characterize the microbial composition in patients with ASD, the results are heterogeneous. Nevertheless, it is clear that there is a difference in the composition of the gut microbiota between ASD and typically developed individuals, and animal studies have repeatedly suggested that the gut microbiota plays an important role in ASD pathophysiology. This possibility is supported by abnormalities in metabolites produced by the gut microbiota and the association between altered immune responses and the gut microbiota observed in ASD patients. Based on these findings, various attempts have been made to use the microbiota in ASD treatment. The results reported to date suggest that microbiota-based therapies may be effective for ASD, but largescale, well-designed studies are needed to confirm this.

목차

INTRODUCTION
GI DISTURBANCE AS A COMMON COMORBIDITY OF ASD
MECHANISM OF GI IMPAIRMENT AND THE GUT MICROBIOTA IN ASD
CHANGES IN GUT MICROBIOTA COMPOSITION IN ASD
ASSOCIATION BETWEEN THE GUT MICROBIOTA AND ASD-RELEVANT BEHAVIORS
METABOLITES INDUCED BY THE GUT MICROBIOTA IN ASD
ALTERED IMMUNE RESPONSE IN ASD AND THE GUT MICROBIOTA
THERAPEUTIC APPROACHES VIA THE GUT MICROBIOTA FOR ASD
CONCLUSION
REFERENCES

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