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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Background: It is still unclear the ideal vitamin D dosage once the deficiency and insufficiency is treated. Once deficiency was corrected we prospectively treated patients with 2,000 IU of vitamin D3 to check whether this dosage is enough to keep them above the 30 ng/mL of 25-hydroxy-vitamin D (25[OH]D). Methods: One hundred and thirty-five Saudi Arabian men and women treatment naïve for the vitamin D deficiency and insufficiency were part of this study. History and clinical examination were done to rule out any metabolic bone disease. Weight and height was taken to calculate the body mass index (BMI). Patients who were vitamin D deficient (≥30 ng/mL), a standard treatment of 50,000 IU of vitamin D3 weekly for 3 months, a blood test for the vitamin D levels at the end of 3 months, maintenance dose of 2,000 IU of vitamin D3 for 3 months and a third blood sample after 3 months. Results: The data for 128 patients was available for analysis. The average age was 44.95±12.97 years with the mean BMI of 29.60±2.59 kg/m2. The baseline 25(OH)D level was 13.16±3.30 ng/mL. The increase in the level of 25(OH)D on 50,000 IU weekly was significant from 13.16±3.3 ng/mL to 36.97±4.67 ng/mL (P<0.001) and then 2,000 IU daily for next 3 months, the level of 25(OH)D dropped top 20.38±5.42 ng/mL (P<0.001). Conclusions: Our study indicates that the maintenance dose of 2,000 IU of vitamin D is not enough for patients to keep the 25(OH)D levels above 30 ng/mL.
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참고문헌 (16)
참고문헌 신청
Autier P / 2014 / Vitamin D status and ill health: a systematic review / Lancet Diabetes Endocrinol 2:76~89
Holick MF / 2003 / Vitamin D: a millenium perspective / J Cell Biochem 88:296~307
Holick MF / 2006 / Resurrection of vitamin D deficiency and rickets / J Clin Invest 116:2062~2072
Ross AC / 2011 / The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know / J Clin Endocrinol Metab 96:53~58
Institute of Medicine / 2011 / Dietary reference intakes for calcium and vitamin D / The National Academies Press
Holick MF / 2003 / Vitamin D: a millenium perspective / J Cell Biochem 88:296~307
Holick MF / 2006 / Resurrection of vitamin D deficiency and rickets / J Clin Invest 116:2062~2072
Ross AC / 2011 / The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know / J Clin Endocrinol Metab 96:53~58
Institute of Medicine / 2011 / Dietary reference intakes for calcium and vitamin D / The National Academies Press
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