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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제25권 제7호
- 발행연도
- 2015.1
- 수록면
- 1,036 - 1,046 (11page)
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Extracts from Asian medicinal herbs are known to be successful therapeutic agents against cancer. In this study, the effects of three types of herbal extracts on anti-tumor growth were examined. Among the three types of herbal extracts, H9 showed stronger anti-tumor growth effects than H5 and H11 in vivo. To find the molecular mechanism by which H9 inhibited the proliferation of breast cancer cell lines, the levels of apoptotic markers were examined. Proapoptotic markers, including cleaved PARP and cleaved caspases 3 and 9, were increased, whereas the anti-apoptotic marker Bcl-2 was decreased by H9 treatment. Next, the combined effect of H9 with the chemotherapeutic drugs doxorubicin/cyclophosphamide (AC) on tumor growth was examined using 4T1-tumor-bearing mice. The combined treatment of H9 with AC did not show additive or synergetic anti-tumor growth effects. However, when tumor-bearing mice were co-treated with H9 and the targeted anti-tumor drug trastuzumab, a delay in tumor growth was observed. The combined treatment of H9 and trastuzumab caused an increase of natural killer (NK) cells and a decrease of myeloid-derived suppressor cells (MDSC). Taken together, H9 induces the apoptotic death of tumor cells while increasing anti-tumor immune activity through the enhancement of NK activity and diminishment of MDSC.
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참고문헌 (24)
참고문헌 신청
Alkreathy HM / 2012 / Mechanisms of cardioprotective effect of aged garlic extract against doxorubicin-induced cardiotoxicity / Integr. Cancer Ther 11 : 364 ~ 370
Bak Y / 2013 / A1E inhibits proliferation and induces apoptosis in NCI-H460 lung cancer cells via extrinsic and intrinsic pathways / Mol. Biol. Rep 40 : 4507 ~ 4519
Cai Y / 2004 / Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancer / Life Sci 74 : 2157 ~ 2184
Chen X / 2014 / Curcumol exhibits anti-inflammatory properties by interfering with the JNK-mediated AP-1 pathway in lipopolysaccharideactivated RAW264.7 cells / Eur. J. Pharm
Chu Q / 2009 / Antitumor potential of three herbal extracts against human oral squamous cell lines / Anticancer Res 29 : 3211 ~ 3219
Bak Y / 2013 / A1E inhibits proliferation and induces apoptosis in NCI-H460 lung cancer cells via extrinsic and intrinsic pathways / Mol. Biol. Rep 40 : 4507 ~ 4519
Cai Y / 2004 / Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancer / Life Sci 74 : 2157 ~ 2184
Chen X / 2014 / Curcumol exhibits anti-inflammatory properties by interfering with the JNK-mediated AP-1 pathway in lipopolysaccharideactivated RAW264.7 cells / Eur. J. Pharm
Chu Q / 2009 / Antitumor potential of three herbal extracts against human oral squamous cell lines / Anticancer Res 29 : 3211 ~ 3219
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