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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.3
- 수록면
- 202 - 209 (8page)
- DOI
- 10.14348/molcells.2015.2356
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초록· 키워드
오류제보하기
Hepatocellular carcinoma (HCC), a highly malignant disease and the third leading cause of all cancer mortalities worldwide, often responses poorly to current treatments and results in dismal outcomes due to frequent chemoresistance and tumor relapse. The heterogeneity of HCC is an important attribute of the disease. It is the outcome of many factors, including the cross-talk between tumor cells within the tumor microenvironment and the acquisition and accumulation of genetic and epigenetic alterations in tumor cells. In addition, there is accumulating evidence in recent years to show that the malignancy of HCC can be attributed partly to the presence of cancer stem cell (CSC). CSCs are capable to self-renew, differentiate and initiate tumor formation. The regulation of the stem cell-like properties by several important signaling pathways have been found to endow the tumor cells with an increased level of tumorigenicity, chemoresistance, and metastatic ability. In this review, we will discuss the recent findings on hepatic CSCs, with special emphasis on their putative origins, relationship with hepatitis viruses, regulatory signaling networks, tumor microenvironment, and how these factors control the stemness of hepatic CSCs. We will also discuss some novel therapeutic strategies targeted at hepatic CSCs for combating HCC and perspectives of future investigation.
목차
등록된 정보가 없습니다.
참고문헌 (76)
참고문헌 신청
Akita, H. / 2014 / MYC activates stem-like cell potential in hepatocarcinoma by a p53-dependent mechanism / Cancer Res 74:5903~5913
Ali, N. / 2011 / Hepatitis C virus-induced cancer stem cell-like signatures in cell culture and murine tumor xenografts / J. Virol 85:12292~12303
Altekruse, S. F. / 2009 / Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005 / J. Clin. Oncol 27:1485~1491
Arzumanyan, A. / 2011 / Does the hepatitis B antigen HBx promote the appearance of liver cancer stem cells / Cancer Res 71:3701~3708
Avila, M. A. / 2000 / Reduced mRNA abundance of the main enzymes involved in methionine metabolism in human liver cirrhosis and hepatocellular carcinoma / J. Hepatol 33:907~914
Ali, N. / 2011 / Hepatitis C virus-induced cancer stem cell-like signatures in cell culture and murine tumor xenografts / J. Virol 85:12292~12303
Altekruse, S. F. / 2009 / Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005 / J. Clin. Oncol 27:1485~1491
Arzumanyan, A. / 2011 / Does the hepatitis B antigen HBx promote the appearance of liver cancer stem cells / Cancer Res 71:3701~3708
Avila, M. A. / 2000 / Reduced mRNA abundance of the main enzymes involved in methionine metabolism in human liver cirrhosis and hepatocellular carcinoma / J. Hepatol 33:907~914
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