지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 432 - 440 (9page)
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초록· 키워드
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Background: Skin hydration is a common problem both in elderly and young people as dry skin may cause irritation, dermatological disorders, and wrinkles. While both genetic and environmental factors seem to influence skin hydration, thorough genetic studies on skin hydration have not yet been conducted. Objective: We used a genome-wide association study (GWAS) to explore the genetic elements underlying skin hydration by regulating epidermal differentiation and skin barrier function. Methods: A GWAS was conducted to investigate the genetic factors influencing skin hydration in 100 Korean females along with molecular studies of genes in human epidermal keratinocytes for functional study in vitro. Results: Among several single nucleotide polymorphisms identified in GWAS, we focused on Single Stranded DNA Binding Protein 3 (SSBP3) which is associated with DNA replication and DNA damage repair. To better understand the role of SSBP3 in skin cells, we introduced a calcium-induced differentiation keratinocyte culture system model and found that SSBP3 was upregulated in keratinocytes in a differentiation dependent manner. When SSBP3 was overexpressed using a recombinant adenovirus, the expression of differentiation-related genes such as loricrin and involucrin was markedly increased. Conclusion: Taken together, our results suggest that genetic variants in the intronic region of SSBP3 could be determinants in skin hydration of Korean females. SSBP3 represents a new candidate gene to evaluate the molecular basis of the hydration ability in individuals.
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참고문헌 (25)
참고문헌 신청
White-Chu EF / 2011 / Dry skin in the elderly: complexities of a common problem / Clin Dermatol 29:37~42
Kalinin AE / 2002 / Epithelial barrier function: assembly and structural features of the cornified cell envelope / Bioessays 24:789~800
Lebwohl M / 2005 / Impaired skin barrier function in dermatologic disease and repair with moisturization / Cutis 76(6 Suppl):7~12
Candille SI / 2012 / Genome-wide association studies of quantitatively measured skin, hair, and eye pigmentation in four European populations / PLoS One 7:e48294
Zhang M / 2013 / Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans / Hum Mol Genet 22:2948~2959
Kalinin AE / 2002 / Epithelial barrier function: assembly and structural features of the cornified cell envelope / Bioessays 24:789~800
Lebwohl M / 2005 / Impaired skin barrier function in dermatologic disease and repair with moisturization / Cutis 76(6 Suppl):7~12
Candille SI / 2012 / Genome-wide association studies of quantitatively measured skin, hair, and eye pigmentation in four European populations / PLoS One 7:e48294
Zhang M / 2013 / Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans / Hum Mol Genet 22:2948~2959
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