지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 279 - 285 (7page)
이용수
초록· 키워드
오류제보하기
Background: Skin keratinocytes participate actively in inducing immune responses when external pathogens are introduced, thereby contributing to elimination of pathogens. However, in condition where the excessive inflammation is occurred, chronic skin disease such as psoriasis can be provoked. Objective: We tried to screen the putative therapeutics for inflammatory skin disease, and found that salvianolic acid A (SAA) has an inhibitory effect on keratinocyte inflammatory reaction. The aim of this study is to demonstrate the effects of SAA in poly(I:C)-induced inflammatory reaction in skin keratinocytes. Methods: We pre-treated keratinocytes with SAA then stimulated with poly(I:C). Inflammatory reaction of keratinocytes was verified using real-time polymerase chain reaction, enzyme-linked immunosorbent assay and Western blot. Results: When skin keratinocytes were pre-treated with SAA, it significantly inhibited poly (I:C)-induced expression of inflammatory cytokines including interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor-α, and CCL20. SAA inhibited poly(I:C)-induced activation of nuclear factor-κB signaling. And SAA also inhibited inflammasome activation, evidenced by decrease of IL-1β secretion. Finally, SAA markedly inhibited poly(I:C)-induced NLRP3 expression. Conclusion: These results demonstrate that SAA has an inhibitory effect on poly(I:C)-induced inflammatory reaction of keratinocytes, suggesting that SAA can be developed for the treatment of inflammatory skin diseases such as psoriasis.
목차
등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Nemes Z / 1999 / Bricks and mortar of the epidermal barrier / Exp Mol Med 31:5~19
Trinchieri G / 2007 / Cooperation of Toll-like receptor signals in innate immune defence / Nat Rev Immunol 7:179~190
Greb JE / 2016 / Psoriasis / Nat Rev Dis Primers 2:16082
Hawkes JE / 2017 / Psoriasis pathogenesis and the development of novel targeted immune therapies / J Allergy Clin Immunol 140:645~653
Kim J / 2015 / The immunopathogenesis of psoriasis / Dermatol Clin 33:13~23
Trinchieri G / 2007 / Cooperation of Toll-like receptor signals in innate immune defence / Nat Rev Immunol 7:179~190
Greb JE / 2016 / Psoriasis / Nat Rev Dis Primers 2:16082
Hawkes JE / 2017 / Psoriasis pathogenesis and the development of novel targeted immune therapies / J Allergy Clin Immunol 140:645~653
Kim J / 2015 / The immunopathogenesis of psoriasis / Dermatol Clin 33:13~23
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Ampelopsis japonica Makino Extract Inhibits the Inflammatory Reaction Induced by Pathogen-Associated Molecular Patterns in Epidermal Keratinocytes
Annals of Dermatology
2016 .01
-
Serum Amyloid A1: A Biomarker for Neutrophilic Airway Inflammation in Adult Asthmatic Patients
Allergy, Asthma & Immunology Research
2022 .01
-
Amyloid beta plaque accumulation and memory function decline exacerbated by SAA1 in Alzheimer’s disease
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Aster glehni Ethanol Extract Inhibits Inflammatory Responses Regulating Skin Barrier Molecules in Human Keratinocytes
Natural Product Sciences
2024 .12
-
Serum amyloid A1 aggravates Alzheimer’s disease through amyloid beta plaque accumulation and memory function decline
한국실험동물학회 학술발표대회 논문집
2021 .01
-
Induction of Interleukin-22 (IL-22) production in CD4+ T Cells by IL-17A Secreted from CpG-Stimulated Keratinocytes
Annals of Dermatology
2016 .01
-
Serum amyloid A1 induces IL-17 secretion in γδ T cell and psoriatic symptoms via TLR2 in transgenic mice
한국실험동물학회 학술발표대회 논문집
2021 .07
-
IL-1 Receptor Antagonist Reduced Chemical-Induced Keratinocyte Apoptosis through Antagonism to IL-1α/IL-1β
Biomolecules & Therapeutics(구 응용약물학회지)
2018 .01
-
Serum amyloid A1 increases IL-17 release in gammadelta T cells and psoriatic symptoms via Toll-like receptor2
한국실험동물학회 학술발표대회 논문집
2021 .01
-
Augmented Serum Amyloid A1/2 Mediated by TNF-induced NF-kB in Human Serous Ovarian Epithelial Tumors
Immune Network
2017 .04
-
Localization of Serum Amyloid A3 in the Mouse Ovary
Immune Network
2017 .08
-
Regulation of serum amyloid A (SAA) and its association with SAA1-derived amyloid deposition in a hepatic SAA1-overexpression mouse
한국실험동물학회 학술발표대회 논문집
2015 .02
-
Comparison of serum amyloid A protein and C-reactive protein levels as inflammatory markers in periodontitis
Journal of Periodontal & Implant Science
2015 .01
-
Keratinocytes-Derived Reactive Oxygen Species Play an Active Role to Induce Type 2 Inflammation of the Skin: A Pathogenic Role of Reactive Oxygen Species at the Early Phase of Atopic Dermatitis
Annals of Dermatology
2021 .01
-
Potential Role of Cytosolic RNA Sensor MDA5 as an Inhibitor for Keratinocyte Differentiation in the Pathogenesis of Psoriasis
Annals of Dermatology
2021 .01
-
Noninvasive Detection of Specific Diagnostic Biomarkers for Atopic Dermatitis
대한의생명과학회지
2019 .03
-
Korean Red Ginseng attenuates ultraviolet-mediated inflammasome activation in keratinocytes
Journal of Ginseng Research
2021 .05
-
Protective role of saponin derived from Korean Red Ginseng in keratinocytes
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Skin Lipid Barrier: Structure, Function and Metabolism
Allergy, Asthma & Immunology Research
2024 .09
-
Single Low-Dose Radiation Induced Regulation of Keratinocyte Differentiation in Calcium-Induced HaCaT Cells
Annals of Dermatology
2016 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0