지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.12
- 수록면
- 36 - 52 (17page)
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초록· 키워드
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Several gut commensals have been shown to modulate host immune response. Recently, many food derived microbes have also been reported to affect the immune system. However, a mechanism to identify immunostimulatory and immunoregulatory microbes is needed. Here, we successfully established an in vitro screening system and identified an immunoregulatory bacterium, Lactobacillus pentosus KF340 (LP340), present in various fermented foods. LP340 induced a regulatory phenotype in mice Ag presenting cells which, in turn, induced IL-10 and IFN-γ producing Type 1 regulatory T cells (Tr1 cells) from naïve CD4+ T cells. Naïve CD4+ T cells co-cultured with LP340 treated dendritic cells highly expressed cytokine receptor IL-27R and were CD49b and lymphocyte-activation gene 3 double positive. Oral administration of LP340 in mice with atopic dermatitis reduced cellular infiltration in affected ear lobes and serum IgE levels, thus, ameliorating the disease symptoms. This suggests a systemic immunoregulatory effect of LP340. These findings demonstrate that LP340, a bacterium derived from food, prevents systemic inflammation through the induction of IL-10 producing Tr1 cells.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (54)
참고문헌 신청
Gensollen T / 2016 / How colonization by microbiota in early life shapes the immune system / Science 352:539~544
Mosconi I / 2013 / Intestinal bacteria induce TSLP to promote mutualistic T-cell responses / Mucosal Immunol 6:1157~1167
Gomez de Agüero M / 2016 / The maternal microbiota drives early postnatal innate immune development / Science 351:1296~1302
Kwon HK / 2010 / Generation of regulatory dendritic cells and CD4+Foxp3+ T cells by probiotics administration suppresses immune disorders / Proc Natl Acad Sci U S A 107:2159~2164
Abdel-Gadir A / 2019 / Microbiota therapy acts via a regulatory T cell MyD88/RORγt pathway to suppress food allergy / Nat Med 25:1164~1174
Mosconi I / 2013 / Intestinal bacteria induce TSLP to promote mutualistic T-cell responses / Mucosal Immunol 6:1157~1167
Gomez de Agüero M / 2016 / The maternal microbiota drives early postnatal innate immune development / Science 351:1296~1302
Kwon HK / 2010 / Generation of regulatory dendritic cells and CD4+Foxp3+ T cells by probiotics administration suppresses immune disorders / Proc Natl Acad Sci U S A 107:2159~2164
Abdel-Gadir A / 2019 / Microbiota therapy acts via a regulatory T cell MyD88/RORγt pathway to suppress food allergy / Nat Med 25:1164~1174
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UCI(KEPA) : I410-ECN-0101-2020-517-000376105