지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.9
- 수록면
- 50 - 59 (10page)
이용수
초록· 키워드
오류제보하기
Background: In Asian countries, including Korea, lead poisoning caused by traditional herbal medicines is often observed in the clinic. However, there have been no reports thus far of lead poisoning caused by drugs that were approved by the Korea Food and Drug Administration (KFDA). Here, we describe seven patients who ingested a problematic natural product-derived drug (NPD).
Case presentation: In July 2018, seven patients visited a university hospital after ingesting an NPD, S. capsules. These patients complained of various symptoms, and their blood lead levels (BLLs) were elevated relative to those of the general population (arithmetic mean: 19.5 ± 11.6 μg/dL, range: 6.28–35.25 μg/dL). The total doses and BLLs were directly proportional to each other among the patients (r = 0.943, p = 0.001). After the patients discontinued drug intake, their BLLs decreased gradually. The capsule was confirmed to contain lead above the standard value (arithmetic mean: 2,547 ± 1,821.9 ppm).
Conclusion: This incident highlights the need to strengthen standards for the management of NPD ingredients in Korea. NPDs are more likely to be contaminated than other drugs. Thorough management by the KFDA is essential to prevent a recurrence. Moreover, systematic health care is needed for many patients who have taken problematic NPDs.
Case presentation: In July 2018, seven patients visited a university hospital after ingesting an NPD, S. capsules. These patients complained of various symptoms, and their blood lead levels (BLLs) were elevated relative to those of the general population (arithmetic mean: 19.5 ± 11.6 μg/dL, range: 6.28–35.25 μg/dL). The total doses and BLLs were directly proportional to each other among the patients (r = 0.943, p = 0.001). After the patients discontinued drug intake, their BLLs decreased gradually. The capsule was confirmed to contain lead above the standard value (arithmetic mean: 2,547 ± 1,821.9 ppm).
Conclusion: This incident highlights the need to strengthen standards for the management of NPD ingredients in Korea. NPDs are more likely to be contaminated than other drugs. Thorough management by the KFDA is essential to prevent a recurrence. Moreover, systematic health care is needed for many patients who have taken problematic NPDs.
목차
ABSTRACT
BACKGROUND
CASE PRESENTATION
DISCUSSION AND CONCLUSION
REFERENCES
참고문헌 (22)
참고문헌 신청
Lewis R / 2014 / Current occupational & environmental medicine / McGraw-Hill :471~474
김지혜 / 2014 / Blood lead levels of Korean lead workers in 2003.2011 / Annals of Occupational and Environmental Medicine 26(4):1~7
Muntner P / 2005 / Continued decline in blood lead levels among adults in the United States: the National Health and Nutrition Examination Surveys / Arch Intern Med 165(18):2155~2161
예한희 / 2013 / A Case of Lead Poisoning due to a Mixture of Talisman Ash / Annals of Occupational and Environmental Medicine 25(4):37~37
Ministry of Health and Welfare / Korea Health Statistics 2016: Korea National Health and Nutrition Examination Survey (KNHANES VII-1)
김지혜 / 2014 / Blood lead levels of Korean lead workers in 2003.2011 / Annals of Occupational and Environmental Medicine 26(4):1~7
Muntner P / 2005 / Continued decline in blood lead levels among adults in the United States: the National Health and Nutrition Examination Surveys / Arch Intern Med 165(18):2155~2161
예한희 / 2013 / A Case of Lead Poisoning due to a Mixture of Talisman Ash / Annals of Occupational and Environmental Medicine 25(4):37~37
Ministry of Health and Welfare / Korea Health Statistics 2016: Korea National Health and Nutrition Examination Survey (KNHANES VII-1)
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