What predicts better prognosis in elderly breast cancer patients?

Youn Joo Jung; Seungju Lee; Hyun Yul Kim; Hyun-June Paik; Chang Shin Jung; Jee Yeon Kim; Hyuk Jae Jung; Seokwon Lee; Choongrak Kim

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자료유형: 학술저널

저자정보: Youn Joo Jung (Pusan National University School of Medicine) Seungju Lee (Pusan National University School of Medicine) Hyun Yul Kim (Pusan National University School of Medicine) Hyun-June Paik (Pusan National University School of Medicine) Chang Shin Jung (Pusan National University School of Medicine) Jee Yeon Kim (Pusan National University School of Medicine) Hyuk Jae Jung (Pusan National University School of Medicine) Seokwon Lee (Pusan National University School of Medicine) Choongrak Kim (Pusan National University)

저널정보: 대한종양외과학회 KOREAN JOURNAL OF CLINICAL ONCOLOGY Korean Journal of Clinical Oncology 제16권 제1호

발행연도: 2020.6

수록면: 52 - 56 (5page)

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Purpose: As we enter an aging society, the number of elderly patients with breast cancer is increasing. We assessed the prognostic factors for breast cancer recurrence or metastasis in patients over the age of 65 years by analyzing tumor characteristics and long-term clinical outcomes.
Methods: In this retrospective study, the data of 286 breast cancer patients aged 65 years and older, who underwent treatment at the Pusan National University Hospital and Pusan National University Yangsan Hospital from 2008 to 2014, were analyzed. The patients were divided into two groups: those with recurrence or metastasis and those without. Cox-regression model was used to analyze the risk factors for recurrence or metastasis. Kaplan-Meier method was used to analyze survival rates by the log-rank test.
Results: Among the 286 patients with invasive breast cancer, 43 patients (15.0%) had recurrence or distant metastasis during a median follow-up period of 61 months. Advanced stages of breast cancer and patients who are not adapted to endocrine therapy were associated with poor prognosis.
Conclusion: In this study, advanced stages of breast cancer and endocrine therapy were the prognostic factors for breast cancer recurrences or metastases. Early detection of elderly breast cancer generally increases the possibility of diagnosis at an earlier stage, which can lead to a better prognosis. Moreover, endocrine therapy should be administered to elderly patients who manifest favorable intrinsic subtypes of breast cancer.

#Breast neoplasms #Elderly #Clinical characteristics #Prognosis

참고문헌 (17)

참고문헌 신청

Orimo H / 2006 / Reviewing the definition of elderly / Nihon Ronen Igakkai Zasshi 43:27~34

Orimo H / 2008 / Redefining the concept of elderly : for"successful aging"society / Nihon Rinsho 66:1605~1614

Lee SK / 2019 / Is the high proportion of young age at breast cancer onset a unique feature of Asian breast cancer? / Breast Cancer Res Treat 173:189~199

Keun-YoungYoo / 2002 / Epidemiology of Breast Cancer in Korea: Occurrence, High-Risk Groups, and Prevention / Journal of Korean Medical Science 17(1):1~6

Jiralerspong S / 2016 / Obesity and breast cancer prognosis : evidence, challenges, and opportunities / J Clin Oncol 34:4203~4216

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