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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 53 - 59 (7page)
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Background and Purpose The US Food and Drug Administration approval for perampanel has only recently been expanded to patients as young as 4 years, and so there have been few real-life studies of the effects of perampanel in pediatric patients. The aim of this study was to determine the long-term efficacy, factors affecting treatment response, and tolerability of perampanel as an add-on therapy in pediatric patients aged 4 years or older with epilepsy. Methods This multicenter retrospective observational study collected data from pediatric epilepsy centers of four Korean national universities. Changes in the seizure frequency from baseline, adverse events, and retention rates were obtained at 3, 6, and 12 months. Adverse events and discontinuation profiles were obtained to assess tolerability. Results This study included 220 children and adolescents (117 males and 103 females) aged 4 to 20 years. The overall response rate was 43.6%, and the seizure-freedom rate was 17.7%. Factors affecting a good treatment response were the absence of intellectual disability, small number of concomitant antiepileptic drugs, and low baseline seizure frequency. Eighty-eight patients (40%) experienced adverse events, but they mostly were of mild severity and resolved after the dose reduction or discontinuation of perampanel. The retention rates at 3, 6, and 12 months were 85.0%, 71.8%, and 50.5%, respectively. Conclusions Adjunctive treatment with perampanel was efficacious and tolerated in pediatric patients aged 4 years or older with epilepsy. Early perampanel treatment may help to reduce the burden of their seizures and improve their quality of life.
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참고문헌 (20)
참고문헌 신청
Bhandage AK / 2017 / AMPA, NMDA and kainate glutamate receptor subunits are expressed in human peripheral blood mononuclear cells (PBMCs)where the expression of GluK4 is altered by pregnancy and GluN2D by depression in pregnant women / J Neuroimmunol 305:51~58
Kim HD / 2016 / Review of clinical studies of perampanel in adolescent patients / Brain Behav 6:e00505
Henley JM / 2016 / Synaptic AMPA receptor composition in development, plasticity and disease / Nat Rev Neurosci 17:337~350
Rogawski MA / 2011 / Revisiting AMPA receptors as an antiepileptic drug target / Epilepsy Curr 11:56~63
Plosker GL / 2012 / Perampanel : as adjunctive therapy in patients with partial-onset seizures / CNS Drugs 26:1085~1096
Kim HD / 2016 / Review of clinical studies of perampanel in adolescent patients / Brain Behav 6:e00505
Henley JM / 2016 / Synaptic AMPA receptor composition in development, plasticity and disease / Nat Rev Neurosci 17:337~350
Rogawski MA / 2011 / Revisiting AMPA receptors as an antiepileptic drug target / Epilepsy Curr 11:56~63
Plosker GL / 2012 / Perampanel : as adjunctive therapy in patients with partial-onset seizures / CNS Drugs 26:1085~1096
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